Evidence map›Paper›PMID 36299245›Full record

ArticleDrug delivery2022

Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization and

Touseef Nawaz, Muhammad Iqbal, Barkat Ali Khan, Naveed Ahmed, Asif Nawaz, Akhtar Rasul, Waleed Y Rizg, Abdulmajeed M Jali, Rayan A Ahmed, Awaji Y Safhi

Abstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Touseef NawazDrug Delivery and Cosmetic Lab (DDCL), Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Muhammad IqbalDrug Delivery and Cosmetic Lab (DDCL), Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Barkat Ali KhanDrug Delivery and Cosmetic Lab (DDCL), Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Naveed AhmedDepartment of Pharmacy, Quaid-i-Azam University Islamabad, Pakistan.ORCID 0000-0002-4780-9945
Asif NawazDrug Delivery and Cosmetic Lab (DDCL), Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Akhtar RasulDepartment of Pharmaceutics, Government College University, Faisalabad, Pakistan.ORCID 0000-0002-9321-0087
Waleed Y RizgDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0002-3088-4084
Abdulmajeed M JaliDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan, Saudi Arabia.
Rayan A AhmedDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan, Saudi Arabia.ORCID 0000-0002-8675-1264
Awaji Y SafhiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous burn wounds are a common and troublesome critical issue of public health. Over the last decade, many researchers have investigated the development of novel therapeutic modalities which are capable of fully regeneration and reinstatement of structure and function of the skin with no or limited scar formation. Novel pharmaceutical carriers are offering a potential platform to deliver the drug effectively and to overcome the limitation associated with conventional wound dressings. The aim of this study was to investigate a pharmaceutical acriflavine-loaded polycaprolactone nanoemulsion (ACR-PCL-NE) for burn wound healing. Nanoemulsion was prepared by using the double emulsion solvent evaporation technique and it was subjected to thermodynamic stability testing, droplet size, polydispersity, zeta potential, pH, and surface morphology analysis. The

Indexed as

AcriflavineBurnsAnimalsEmulsionsParticle SizePolyestersRatsRats, Sprague-DawleySolventsWound HealingAcriflavineEmulsionspolycaprolactonePolyestersSolventsacriflavineburn wounddrug deliveryNanoemulsiontopical

Identifiers

PMID36299245
PMCPMC9621282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.