Evidence map›Paper›PMID 36298843›Full record

ArticleViruses2022

Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.

Emily Cruz-Lorenzo, Nora-Guadalupe P Ramirez, Jeon Lee, Sonali Pandhe, Lei Wang, Juan Hernandez-Doria, Adam M Spivak, Vicente Planelles, Tianna Petersen, Mamta K Jain and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Emily Cruz-LorenzoDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Nora-Guadalupe P RamirezDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jeon LeeLydia Hill Department of Bioinformatics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9071-7157
Sonali PandheDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lei WangDepartment of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Juan Hernandez-DoriaDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Adam M SpivakDivision of Infectious Diseases, Department of Medicine, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-1815-7893
Vicente PlanellesDepartment of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Tianna PetersenDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Mamta K JainDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Elisabeth D MartinezDepartment of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Iván D'OrsoDepartment of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1409-2351
The University of Texas Southwestern Medical Center · USUniversity of Utah · USParkland Health & Hospital System · US

Funding

Transcriptional regulatory mechanisms shaping HIV proviral fateR01AI114362 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI D'ORSO, IVAN · 2015 to 2024
$4.6M
Novel small molecules to reactivate latent HIV and sensitize to anti-viral therapiesR33AI116222 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI D'ORSO, IVAN, MARTINEZ, ELISABETH D · 2016 to 2018
$1.5M
Transcriptional regulatory mechanisms shaping HIV proviral fateR37AI114362 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Ivan D'Orso · 2025 to 2026
$1.0M
Novell small molecules to reactivate latent HIV and sensitize to anti-viral therapiesR21AI116222 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI D'ORSO, IVAN, MARTINEZ, ELISABETH D · 2014 to 2015
$437k
NIAID NIH HHS R01 AI114362NIAID NIH HHS R21 AI116222NIAID NIH HHS R33 AI116222NIAID NIH HHS R37 AI114362NIH HHS R01AI114362NIH HHS R21/R33AI116222
6 · The paper itself

Abstract

Immune cell state alterations rewire HIV-1 gene expression, thereby influencing viral latency and reactivation, but the mechanisms are still unfolding. Here, using a screen approach on CD4

Indexed as

HIV-1HIV InfectionsTranscription Factor AP-1Virus ActivationVirus LatencyCD4-Positive T-LymphocytesHIV SeropositivityHumansHypoxia-Inducible Factor 1, alpha SubunitJurkat CellsMitogen-Activated Protein Kinase KinasesOxidation-ReductionHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMitogen-Activated Protein Kinase KinasesTranscription Factor AP-1cell signalingHIV-1latencylatency reversing agentsreactivationtranscription factors

Identifiers

PMID36298843
PMCPMC9612055
OpenAlexW4306773399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.