Evidence map›Paper›PMID 36298717›Full record

ArticleViruses2022

Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents.

Alejandro Flores-Alanis, Zeus Saldaña-Ahuactzi, Israel Parra-Ortega, Pablo López-Ramírez, Marcela Salazar-García, Yolanda P Alemán-García, Armando Cruz-Rangel, Alba Moreno-Paredes, Adrián Diaz-Rojas, Carmen Maldonado-Bernal and 2 more

Abstract readCase Reports
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Neurological manifestations associated with SARS-CoV-2 infection in pediatric patients: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Pooled it
  2. Article
  3. Altered COVID-19 immunity in children with asthma by atopic status.The journal of allergy and clinical immunology. Global · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alejandro Flores-AlanisDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.ORCID 0000-0001-5837-6076
Zeus Saldaña-AhuactziPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-2710-2846
Israel Parra-OrtegaLaboratorio Central, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.ORCID 0000-0002-7195-1749
Pablo López-RamírezCentro de Investigación en Ciencias de Información Geoespacial (CentroGeo), Ciudad de México 14240, Mexico.ORCID 0000-0002-2766-569X
Marcela Salazar-GarcíaLaboratorio de Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.ORCID 0000-0001-5318-8148
Yolanda P Alemán-GarcíaLaboratorio de Investigación en COVID-19, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Armando Cruz-RangelLaboratorio de Bioquímica de Enfermedades Crónicas, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico.ORCID 0000-0002-0113-0312
Alba Moreno-ParedesUnidad de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Adrián Diaz-RojasLaboratorio de Investigación en COVID-19, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Carmen Maldonado-BernalUnidad de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Jessica Quevedo-MoranLaboratorio de Investigación en COVID-19, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Victor M Luna-PinedaLaboratorio de Investigación en COVID-19, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.ORCID 0000-0002-3078-9423

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe analyzed the demographic, clinical, and diagnostic data of children and adolescents in Mexico, from the first case of coronavirus disease (COVID-19) to 28 February 2022.

methodsUsing the open databases of the Ministry of Health and a tertiary pediatric hospital, we obtained demographic and clinical data from the beginning of the COVID-19 pandemic until 28 February 2022. In addition, quantitative reverse-transcription polymerase chain reaction outputs were used to determine the viral load, and structural protein-based serology was performed to evaluate IgG antibody levels.

resultsOf the total 437,832 children and adolescents with COVID-19, 1187 died. Of these patients, 1349 were admitted to the Hospital Infantil de Mexico Federico Gómez, and 11 died. Obesity, asthma, and immunosuppression were the main comorbidities, and fever, cough, and headache were the main symptoms. In this population, many patients have a low viral load and IgG antibody levels.

conclusionDuring the first 2 years of the COVID-19 pandemic in Mexico, children and adolescents had low incidence and mortality. They are a heterogeneous population, but many patients had comorbidities such as obesity, asthma, and immunosuppression; symptoms such as fever, cough, and headache; and low viral load and IgG antibodies.

Indexed as

AsthmaCOVID-19AdolescentChildCoughFeverHeadacheHumansImmunoglobulin GMexicoObesityPandemicsSARS-CoV-2Immunoglobulin Gchildren and adolescentscomorbiditiesCOVID-19epidemiologyIgG antibodiesviral load

Identifiers

PMID36298717
PMCPMC9611217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.