Evidence map›Paper›PMID 36298700›Full record

ArticleViruses2022

Cytokine Profiling of Amniotic Fluid from Congenital Cytomegalovirus Infection.

Nicolas Bourgon, Wendy Fitzgerald, Hugues Aschard, Jean-François Magny, Tiffany Guilleminot, Julien Stirnemann, Roberto Romero, Yves Ville, Leonid Margolis, Marianne Leruez-Ville

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01651585 (In Utero Treatment of Cytomegalovirus congénitale Infection With Valacyclovir), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01651585 phase4completednot on this map

In Utero Treatment of Cytomegalovirus congénitale Infection With Valacyclovir : Prospective Multicenter Nonrandomized Trial

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2011 to 2015Enrolled41ConditionsFoetuses Infection, Cytomegalovirus (CMV)InfectionArmsValacyclovir arrow
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nicolas BourgonService d'Obstétrique-Maternité, Chirurgie, Médecine et Imagerie Fœtales, Hôpital Necker Enfants Malades, GHU Paris Centre, AP-HP, F-75015 Paris, France.ORCID 0000-0003-3093-4085
Wendy FitzgeraldSection of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA.
Hugues AschardDepartment of Computational Biology, Institut Pasteur, Université Paris Cité, F-75015 Paris, France.ORCID 0000-0002-7554-6783
Jean-François MagnyÉquipe d'Accueil «FŒTUS» 73-28, Université Paris Cité, F-75015 Paris, France.
Tiffany GuilleminotÉquipe d'Accueil «FŒTUS» 73-28, Université Paris Cité, F-75015 Paris, France.
Julien StirnemannService d'Obstétrique-Maternité, Chirurgie, Médecine et Imagerie Fœtales, Hôpital Necker Enfants Malades, GHU Paris Centre, AP-HP, F-75015 Paris, France.
Roberto RomeroPerinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA.
Yves VilleService d'Obstétrique-Maternité, Chirurgie, Médecine et Imagerie Fœtales, Hôpital Necker Enfants Malades, GHU Paris Centre, AP-HP, F-75015 Paris, France.
Leonid MargolisSection of Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA.
Marianne Leruez-VilleÉquipe d'Accueil «FŒTUS» 73-28, Université Paris Cité, F-75015 Paris, France.
Hôpital Necker-Enfants Malades · FRNational Institutes of Health · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital cytomegalovirus (cCMV) infection is frequent and potentially severe. The immunobiology of cCMV infection is poorly understood, involving cytokines that could be carried within or on the surface of extracellular vesicles (EV). We investigated intra-amniotic cytokines, mediated or not by EV, in cCMV infection.

methodsForty infected fetuses following early maternal primary infection and forty negative controls were included. Infected fetuses were classified according to severity at birth: asymptomatic, moderately or severely symptomatic. Following the capture of EV in amniotic fluid (AF), the concentrations of 38 cytokines were quantified. The association with infection and its severity was determined using univariate and multivariate analysis. A prediction analysis based on principal component analysis was conducted.

resultscCMV infection was nominally associated with an increase in six cytokines, mainly soluble (IP-10, IL-18, ITAC, and TRAIL). EV-associated IP-10 was also increased in cases of fetal infection. Severity of fetal infection was nominally associated with an increase in twelve cytokines, including five also associated with fetal infection. A pattern of specific increase in six proteins fitted severely symptomatic infection, including IL-18soluble, TRAILsoluble, CRPsoluble, TRAILsurface, MIGinternal, and RANTESinternal.

conclusionFetal infection and its severity are associated with an increase in pro-inflammatory cytokines involved in Th1 immune response.

Indexed as

Cytomegalovirus InfectionsPregnancy Complications, InfectiousAmniotic FluidChemokine CXCL10CytokinesFemaleHumansInfant, NewbornInterleukin-18PregnancyChemokine CXCL10CytokinesInterleukin-18amniotic fluidcongenital cytomegalovirus infectioncytokinesextracellular vesicles

Identifiers

PMID36298700
PMCPMC9607316
OpenAlexW4298002242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.