The Interaction between B87 Vaccine Strain and BC6/85 of Infectious Bursa Disease Virus in SPF Chickens.

Ling Chen, Xiaoyue Yang, Yafen Song, Taozhen Jiang

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In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Ling ChenDepartment of Veterinary Culture Collection and Detection, China Institute of Veterinary Drug Control, No. 8 South Street, Zhongguancun, Haidian District, Beijing 100081, China.

Xiaoyue YangDepartment of Veterinary Culture Collection and Detection, China Institute of Veterinary Drug Control, No. 8 South Street, Zhongguancun, Haidian District, Beijing 100081, China.

Yafen SongDepartment of Veterinary Culture Collection and Detection, China Institute of Veterinary Drug Control, No. 8 South Street, Zhongguancun, Haidian District, Beijing 100081, China.

Taozhen JiangDepartment of Veterinary Culture Collection and Detection, China Institute of Veterinary Drug Control, No. 8 South Street, Zhongguancun, Haidian District, Beijing 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was initiated to determine the interaction between two infectious bursal disease virus (IBDV) strains in the early stages of infection by detection and quantification of IBDV RNA in lymphoid and non-lymphoid tissues. SPF chickens were inoculated with single infection or dual infection by the mild strain B87 followed by the pathogenic strain BC6/85 at 0, 1, 2, and 3 days post-inoculation (dpi) with B87. Real-time RT-PCR assays were developed to examine the viral loads of the tissues collected at various time intervals. The results reveal that B87 could delay the time point of positive detection of the BC6/85 strain in the bursa of Fabricius from 1 dpi to 3 dpi, indicating that B87 interfered with the replication of BC6/85. The interference occurred when BC6/85 was inoculated at 2 dpi and 3 dpi with the B87 strain. Moreover, BC6/85 could affect the proliferation and duration of B87 in SPF chickens. The rates of positive detection for B87 decreased significantly during dual infection. The investigation of the interaction between the two strains is important for the implementation of appropriate control measures.

Indexed as

Birnaviridae InfectionsInfectious bursal disease virusPoultry DiseasesVaccinesAnimalsBursa of FabriciusChickensRNASpecific Pathogen-Free OrganismsRNAVaccinesB87 and BC6/85IBDVviral interferencevirus quantification

Identifiers

PMID36298666

DOI10.3390/v14102111

PMCPMC9611333

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