Evidence map›Paper›PMID 36298664›Full record

ArticleViruses2022

Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice.

Cui-Cui Liu, De-Jian Liu, Xin-Yu Yue, Xiu-Qin Zhong, Xuan Wu, Hai-Yan Chang, Bao-Zhong Wang, Mu-Yang Wan, Lei Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Cui-Cui LiuHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.
De-Jian LiuHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.
Xin-Yu YueHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.ORCID 0000-0003-1427-7548
Xiu-Qin ZhongHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.ORCID 0000-0002-4772-4255
Xuan WuHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.
Hai-Yan ChangCollege of Life Sciences, Hunan Normal University, Changsha 410082, China.
Bao-Zhong WangCenter for Inflammation, Immunity & Infection, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-1561-4318
Mu-Yang WanHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.
Lei DengHunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China.ORCID 0000-0002-2818-0432
Hunan University · CNGeorgia State University · USHunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza virus hemagglutinin (HA) stem is currently regarded as an extremely promising immunogen for designing universal influenza vaccines. The appropriate antigen-presenting vaccine vector would be conducive to increasing the immunogenicity of the HA stem antigen. In this study, we generated chimeric virus-like particles (cVLPs) co-displaying the truncated C-terminal of DnaK from

Indexed as

Influenza, HumanInfluenza VaccinesOrthomyxoviridaeOrthomyxoviridae InfectionsVaccines, Virus-Like ParticleAnimalsAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsHumansMiceMice, Inbred BALB CAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsInfluenza VaccinesVaccines, Virus-Like ParticleDnaKhemagglutinin steminfluenza virusuniversal vaccinevirus-like particle

Identifiers

PMID36298664
PMCPMC9610613
OpenAlexW4298002315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.