Evidence map›Paper›PMID 36298589›Full record

ArticleVaccines2022

Development of the Sm14/GLA-SE Schistosomiasis Vaccine Candidate: An Open, Non-Placebo-Controlled, Standardized-Dose Immunization Phase Ib Clinical Trial Targeting Healthy Young Women.

Marília Santini-Oliveira, Patrícia Machado Pinto, Tatiane Dos Santos, Mônica Magno Vilar, Beatriz Grinsztejn, Valdilea Veloso, Elan C Paes-de-Almeida, Maria A Z Amaral, Celso R Ramos, Miryam Marroquin-Quelopana and 7 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. The efficacy of cercarial antigen loaded on nanoparticles as a potential vaccine candidate inJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Article
  10. Transmission-Blocking Vaccines against Schistosomiasis Japonica.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Human Schistosomiasis Vaccines as Next Generation Control Tools.Tropical medicine and infectious disease · 2023
    Article
  17. Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy.Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Marília Santini-OliveiraEvandro Chagas National Institute of Infectology, Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-0953-1401
Patrícia Machado PintoLaboratory of Experimental Schistosomiasis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21045-900, Brazil.
Tatiane Dos SantosLaboratory of Experimental Schistosomiasis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21045-900, Brazil.
Mônica Magno VilarLaboratory of Experimental Schistosomiasis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21045-900, Brazil.
Beatriz GrinsztejnEvandro Chagas National Institute of Infectology, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Valdilea VelosoEvandro Chagas National Institute of Infectology, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Elan C Paes-de-AlmeidaDepartment of Basic Sciences, Fluminense Federal University, Nova Friburgo 28625-650, Brazil.
Maria A Z AmaralProgram for Development of the Mata Atlântica Campus, Fiocruz, Rio de Janeiro 21045-900, Brazil.
Celso R RamosFenix Biotec Treinamento SS LTDA, São Paulo 05591-090, Brazil.
Miryam Marroquin-QuelopanaFenix Biotec Treinamento SS LTDA, São Paulo 05591-090, Brazil.
Rhea ColerDepartment of Global Health, University of Washington, Seattle, WA 98195, USA.
Steven ReedHDT Bio, Seattle, WA 98102, USA.
Marcia A CiolDepartment of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, WA 98105, USA.
Wilson SavinoLaboratory on Thymus Research, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Juçara de Carvalho ParraRené Rachou Institute-Fiocruz/Minas, Fiocruz, Belo Horizonte 30190-002, Brazil.
Marília Sirianni Dos Santos AlmeidaLaboratory of Experimental Schistosomiasis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21045-900, Brazil.ORCID 0000-0002-5431-4086
Miriam TendlerLaboratory of Experimental Schistosomiasis, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21045-900, Brazil.ORCID 0000-0002-9471-7461
Fundação Oswaldo Cruz · BRInstituto Evandro Chagas · BRUniversity of Washington · USUniversidade Federal Fluminense · BR

Funding

Financiadora de Estudos e Projetos 01.06.105800Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.001533/2014
6 · The paper itself

Abstract

We report the successful closure of Phase I clinical trials, comprising Phases Ia and Ib, of the vaccine candidate against human schistosomiasis: the

Indexed as

phase Ib clinical trialpregnant rabbitsschistosomiasisSm14 proteintoxicologyvaccine

Identifiers

PMID36298589
PMCPMC9607179
OpenAlexW4306404367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.