Evidence map›Paper›PMID 36298548›Full record

ArticleVaccines2022

AddaVax-Adjuvanted H5N8 Inactivated Vaccine Induces Robust Humoral Immune Response against Different Clades of H5 Viruses.

Feixia Gao, Xueying Liu, Yudong Dang, Peng Duan, Wenting Xu, Xin Zhang, Shilei Wang, Jian Luo, Xiuling Li

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feixia GaoShanghai Institute of Biological Products, Shanghai 200052, China.
Xueying LiuShanghai Institute of Biological Products, Shanghai 200052, China.
Yudong DangShanghai Institute of Biological Products, Shanghai 200052, China.
Peng DuanShanghai Institute of Biological Products, Shanghai 200052, China.
Wenting XuShanghai Institute of Biological Products, Shanghai 200052, China.
Xin ZhangShanghai Institute of Biological Products, Shanghai 200052, China.
Shilei WangShanghai Institute of Biological Products, Shanghai 200052, China.
Jian LuoShanghai Institute of Biological Products, Shanghai 200052, China.
Xiuling LiShanghai Institute of Biological Products, Shanghai 200052, China.

Funding

Shanghai Science and Technology Support Program 21S11909700 and 21S11903200
6 · The paper itself

Abstract

Since some cases of human infections with H5N8 avian influenza virus have been reported and caused great concern in recent years, it is important to develop an effective vaccine for human use to prevent a potential H5N8 pandemic. In the present study, a vaccine candidate virus based on newly human-infected A/Astrakhan/3212/2020 H5N8 virus was constructed by reverse genetics (RG) technology. The immunogenicity of H5N8 whole virion inactivated vaccine was evaluated by various doses of vaccine antigen formulated with squalene-based adjuvant (AddaVax), aluminum hydroxide (Al(OH)

Indexed as

AddaVaxH5N8 vaccinehemagglutination inhibitionimmunogenicitymicroneutralizationneuraminidase inhibition

Identifiers

PMID36298548
PMCPMC9612011
OpenAlexW4304190075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.