Evidence map›Paper›PMID 36298513›Full record

ArticleVaccines2022

Unravelling the Differential Host Immuno-Inflammatory Responses to

Ena Gupta, Sanni Kumar, Vijay Kumar Srivastava, Juhi Saxena, Arif Jamal Siddiqui, Sudhir Mehta, Sanket Kaushik, Anupam Jyoti

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Immunoglobulin GFrontiers in immunology · 2026
    Article
  2. Article
  3. Review
  4. A potential XGBoost Diagnostic Score forFrontiers in immunology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ena GuptaAmity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur 303002, Rajasthan, India.ORCID 0000-0002-3857-5825
Sanni KumarAmity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur 303002, Rajasthan, India.ORCID 0000-0003-3616-5483
Vijay Kumar SrivastavaAmity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur 303002, Rajasthan, India.
Juhi SaxenaDepartment of Biotechnology, University Institute of Biotechnology, Chandigarh University, S.A.S Nagar 140413, Punjab, India.ORCID 0000-0001-7555-4292
Arif Jamal SiddiquiDepartment of Biology, College of Science, University of Ha'il, Ha'il P.O. Box 2440, Saudi Arabia.ORCID 0000-0002-6236-0920
Sudhir MehtaDepartment of Geriatric Medicine, SMS Medical College & Attached Hospitals, J.L.N. Marg, Jaipur 302004, Rajasthan, India.
Sanket KaushikAmity Institute of Biotechnology, Amity University Rajasthan, Amity Education Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur 303002, Rajasthan, India.
Anupam JyotiDepartment of Biotechnology, University Institute of Biotechnology, Chandigarh University, S.A.S Nagar 140413, Punjab, India.
Chandigarh University · INSMS Medical College · INUniversity of Ha'il · SA

Funding

Indian Council of Medical Research 2019-5517/CMB-BMS
6 · The paper itself

Abstract

Previous reports from our lab have documented dysregulated host inflammatory reactions in response to bacterial infections in sepsis. Both Gram-negative bacteria (GNB) and Gram-positive bacteria (GPB) play a significant role in the development and progression of sepsis by releasing several virulence factors. During sepsis, host cells produce a range of inflammatory responses including inducible nitric oxide synthase (iNOS) expression, nitrite generation, neutrophil extracellular traps (NETs) release, and pro-inflammatory cytokines production. The current study was conducted to discern the differences in host inflammatory reactions in response to both

Indexed as

bacterial infectionsGram-negativegram-positivehost inflammatory responseiNOSNETspro-inflammatory cytokinetotal nitrite content

Identifiers

PMID36298513
PMCPMC9610428
OpenAlexW4304190108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.