Evidence map›Paper›PMID 36297628›Full record

ArticlePharmaceutics2022

Studying Lipid Membrane Interactions of a Super-Cationic Peptide in Model Membranes and Living Bacteria.

Isabel Pérez-Guillén, Òscar Domènech, Adrià Botet-Carreras, Alexandra Merlos, Josep M Sierra, Fernando Albericio, Beatriz G de la Torre, M Teresa Montero, Miguel Viñas, Jordi H Borrell

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Isabel Pérez-GuillénLaboratory of Molecular Microbiology & Antimicrobials, Faculty of Medicine & Health Sciences, University of Barcelona, 08907 Barcelona, Spain.
Òscar DomènechPhysical Chemistry Section, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-7281-8915
Adrià Botet-CarrerasPhysical Chemistry Section, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-1946-5484
Alexandra MerlosLaboratory of Molecular Microbiology & Antimicrobials, Faculty of Medicine & Health Sciences, University of Barcelona, 08907 Barcelona, Spain.
Josep M SierraLaboratory of Molecular Microbiology & Antimicrobials, Faculty of Medicine & Health Sciences, University of Barcelona, 08907 Barcelona, Spain.ORCID 0000-0002-0997-5619
Fernando AlbericioPeptide Sciences Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, University Road, Westville, Durban 4001, South Africa.ORCID 0000-0002-8946-0462
Beatriz G de la TorreKRISP, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4001, South Africa.ORCID 0000-0001-8521-9172
M Teresa MonteroPhysical Chemistry Section, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
Miguel ViñasLaboratory of Molecular Microbiology & Antimicrobials, Faculty of Medicine & Health Sciences, University of Barcelona, 08907 Barcelona, Spain.ORCID 0000-0003-2073-3386
Jordi H BorrellPhysical Chemistry Section, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-8022-7891
Institut de Nanociència i Nanotecnologia de la Universitat de BarcelonaUniversitat de Barcelona · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESUniversity of KwaZulu-Natal · ZA

Funding

Marato TV3 Foundation BARNAPA
6 · The paper itself

Abstract

The super-cationic peptide dendrimers (SCPD) family is a valuable class of antimicrobial peptide candidates for the future development of antibacterial agents against multidrug-resistant gram-negative bacteria. The deep knowledge of their mechanism of action is a major challenge in research, since it may be the basis for future modifications/optimizations. In this work we have explored the interaction between SCPD and membranes through biophysical and microbiological approaches in the case of the G1OLO-L

Indexed as

anisotropyantimicrobials interactionsatomic force microscopysuper-cationic peptides

Identifiers

PMID36297628
PMCPMC9611851
OpenAlexW4306399301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.