ArticlePharmaceutics2022
Acoustically Driven Cell-Based Microrobots for Targeted Tumor Therapy.
Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- CAMP: Closed-Loop Acoustic-Magnetic Propulsion of Microrobots for Precision Cell Manipulation.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025Article
- Micro- and Nano-Bots for Infection Control.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Multiorifice acoustic microrobot for boundary-free multimodal 3D swimming.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tunable Acoustic Tweezer System for Precise Three-Dimensional Particle Manipulation.Micromachines · 2024Article
- Magnetic-Controlled Microrobot: Real-Time Detection and Tracking through Deep Learning Approaches.Micromachines · 2024Article
- Acoustic Actuators for the Manipulation of Micro/Nanorobots: State-of-the-Art and Future Outlooks.Micromachines · 2024Review
- Article
- Macrophage-Based Microrobots for Anticancer Therapy: Recent Progress and Future Perspectives.Biomimetics (Basel, Switzerland) · 2023Review
- A Review of Single-Cell Microrobots: Classification, Driving Methods and Applications.Micromachines · 2023Review
- Applications and Future Prospects of Micro/Nanorobots Utilizing Diverse Biological Carriers.Micromachines · 2023Review
- Fabrication, Acoustic Characterization and Phase Reference-Based Calibration Method for a Single-Sided Multi-Channel Ultrasonic Actuator.Micromachines · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Targeted drug delivery using microrobots manipulated by an external actuator has significant potential to be a practical approach for wireless delivery of therapeutic agents to the targeted tumor. This work aimed to develop a novel acoustic manipulation system and macrophage-based microrobots (Macbots) for a study in targeted tumor therapy. The Macbots containing superparamagnetic iron oxide nanoparticles (SPIONs) can serve as drug carriers. Under an acoustic field, a microrobot cluster of the Macbots is manipulated by following a predefined trajectory and can reach the target with a different contact angle. As a fundamental validation, we investigated an in vitro experiment for targeted tumor therapy. The microrobot cluster could be manipulated to any point in the 4 × 4 × 4 mm region of interest with a position error of less than 300 μm. Furthermore, the microrobot could rotate in the O-XY plane with an angle step of 45 degrees without limitation of total angle. Finally, we verified that the Macbots could penetrate a 3D tumor spheroid that mimics an in vivo solid tumor. The outcome of this study suggests that the Macbots manipulated by acoustic actuators have potential applications for targeted tumor therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.