Evidence map›Paper›PMID 36297572›Full record

ArticlePharmaceutics2022

Influence of the Hydrophobicity of Pluronic Micelles Encapsulating Curcumin on the Membrane Permeability and Enhancement of Photoinduced Antibacterial Activity.

Maria Antonia Tănase, Andreia Cristina Soare, Lia Mara Diţu, Cristina Lavinia Nistor, Catalin Ionut Mihaescu, Ioana Catalina Gifu, Cristian Petcu, Ludmila Otilia Cinteza

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria Antonia TănasePhysical Chemistry Department, University of Bucharest, 030018 Bucharest, Romania.
Andreia Cristina SoarePhysical Chemistry Department, University of Bucharest, 030018 Bucharest, Romania.
Lia Mara DiţuMicrobiology Department, Faculty of Biology, University of Bucharest, 60101 Bucharest, Romania.ORCID 0000-0002-6593-255X
Cristina Lavinia NistorPolymer Department, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania.ORCID 0000-0002-9200-5807
Catalin Ionut MihaescuPolymer Department, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania.
Ioana Catalina GifuPolymer Department, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania.ORCID 0000-0002-2854-1998
Cristian PetcuPolymer Department, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania.ORCID 0000-0002-0624-4626
Ludmila Otilia CintezaPhysical Chemistry Department, University of Bucharest, 030018 Bucharest, Romania.ORCID 0000-0002-3317-2787
National Institute for Research and Development in Environmental Protection · ROUniversity of Bucharest · RO

Funding

Romanian Ministry of Research and Innovation-MCI through INCDCP ICECHIM Bucharest 2019-2022 Core Program PN. 19.23-Chem-Ergent Project No.19.23.02.03.
6 · The paper itself

Abstract

Apart from its well-known activity as an antimicrobial agent, Curcumin (CURC) has recently started to arouse interest as a photosensitizer in the photodynamic therapy of bacterial infections. The aim of the present study was to evidence the influence of the encapsulation of Curcumin into polymeric micelles on the efficiency of photoinduced microbial inhibition. The influence of the hydrophobicity of the selected Pluronics (P84, P123, and F127) on the encapsulation, stability, and antimicrobial efficiency of CURC-loaded micelles was investigated. In addition, the size, morphology, and drug-loading capacity of the micellar drug delivery systems have been characterized. The influence of the presence of micellar aggregates and unassociated molecules of various Pluronics on the membrane permeability was investigated on both normal and resistant microbial strains of

Indexed as

curcuminmembrane permeabilizationmicrobial photoinactivationphotodynamic therapypolymeric micelles

Identifiers

PMID36297572
PMCPMC9608470
OpenAlexW4303961796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.