Evidence map›Paper›PMID 36297567›Full record

ArticlePharmaceutics2022

The Influence of Local Microstructure Inhomogeneities on Local Drying Kinetics during Freeze-Drying.

Sebastian Gruber, Maximilian Thomik, Nicole Vorhauer-Huget, Lukas Hans, Evangelos Tsotsas, Petra Foerst

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sebastian GruberChair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany.ORCID 0000-0003-2306-4616
Maximilian ThomikDepartment of Thermal Process Engineering, Institute of Process Engineering, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany.
Nicole Vorhauer-HugetDepartment of Thermal Process Engineering, Institute of Process Engineering, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany.
Lukas HansChair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany.
Evangelos TsotsasDepartment of Thermal Process Engineering, Institute of Process Engineering, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany.ORCID 0000-0001-9575-1138
Petra FoerstChair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany.ORCID 0000-0002-6381-1543
Otto-von-Guericke-Universität Magdeburg · DETechnical University of Munich · DE

Funding

Deutsche Forschungsgemeinschaft 413284489
6 · The paper itself

Abstract

Freeze-drying is a gentle drying technique to dry high value products, such as pharmaceuticals, without impacting the quality of the product. However, this method is very time and cost intensive. It is known that larger pores reduce the duration of primary drying due to facilitated mass transport. However, next to the pore size, other structural parameters exist whose influence on drying kinetics is still unknown. Therefore, the aim of this article is to investigate the influence of the microstructure (pore size, shape and orientation) on local primary drying kinetics. In the study, freeze-drying experiments on maltodextrin and sucrose solutions (c

Indexed as

drying kineticsfreeze-dryingimage analysislyomicroscopemaltodextrinmicrostructuresucrose

Identifiers

PMID36297567
PMCPMC9612110
OpenAlexW4303961792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.