Evidence map›Paper›PMID 36297435›Full record

ArticlePharmaceutics2022

In Vivo Evaluation of a Gastro-Resistant HPMC-Based "Next Generation Enteric" Capsule.

Adrian Rump, Marie-Luise Kromrey, Eberhard Scheuch, Vincent Jannin, Lara Rehenbrock, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adrian RumpDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-1335-2809
Marie-Luise KromreyDepartment of Diagnostic Radiology and Neuroradiology, University Hospital Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-0420-7303
Eberhard ScheuchDepartment of Clinical Pharmacology, University Hospital Greifswald, 17487 Greifswald, Germany.
Vincent JanninLonza Capsules & Health Ingredients, 68000 Colmar, France.ORCID 0000-0003-1630-2807
Lara RehenbrockDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.
Mladen Vassilev TzvetkovDepartment of Clinical Pharmacology, University Hospital Greifswald, 17487 Greifswald, Germany.
Werner WeitschiesDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-3492-7747
Michael GrimmDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-1310-7435
Universität Greifswald · DEUniversitätsmedizin Greifswald · DE

Funding

Lonza Capsules & Health Ingredients, Colmar, France n.a.
6 · The paper itself

Abstract

Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place and the potential degradation of fragile APIs during the coating process. Ready-to-use enteric hard capsules would be an easily available alternative to test and develop APIs in enteric formulations, while decreasing the time and cost of process development. In this regard, Lonza Capsugel

Indexed as

caffeineenteric hard capsulehydroxypropyl methyl cellulosehydroxypropyl methyl cellulose acetate succinateMRIsalivastable isotope

Identifiers

PMID36297435
PMCPMC9609816
OpenAlexW4296614824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.