Evidence map›Paper›PMID 36297419›Full record

ReviewPharmaceutics2022

Development of Nasal Vaccines and the Associated Challenges.

Xuanxuan Nian, Jiayou Zhang, Shihe Huang, Kai Duan, Xinguo Li, Xiaoming Yang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Mucosal immunotherapy targeting APC in lung disease.Journal of inflammation (London, England) · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Intranasal and intraperitoneal immunization againstClinical and experimental vaccine research · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xuanxuan NianNational Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China.ORCID 0000-0002-6971-9916
Jiayou ZhangNational Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China.
Shihe HuangNational Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China.
Kai DuanNational Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China.
Xinguo LiNational Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China.
Xiaoming YangNational Engineering Technology Research Center for Combined Vaccines, Wuhan 430207, China.ORCID 0000-0002-2598-4355
Wuhan Institute of Bioengineering · CN

Funding

National Science and Technology Major Project titled "Major New Drug Manufacturing Program" of China 2016ZX09106003-008
6 · The paper itself

Abstract

Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong mucosal and systemic immunity to combat these infections. The intranasal route of vaccination offers the advantage of easy accessibility over the injection administration. Therefore, nasal immunization is considered a promising strategy for disease prevention, particularly in the case of infectious diseases of the respiratory system. The development of a nasal vaccine, particularly the strategies of adjuvant and antigens design and optimization, enabling rapid induction of protective mucosal and systemic responses against the disease. In recent times, the development of efficacious nasal vaccines with an adequate safety profile has progressed rapidly, with effective handling and overcoming of the challenges encountered during the process. In this context, the present report summarizes the most recent findings regarding the strategies used for developing nasal vaccines as an efficient alternative to conventional vaccines.

Indexed as

adjuvantdelivery systemmucosal immunitynasal vaccine

Identifiers

PMID36297419
PMCPMC9609876
OpenAlexW4296742372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.