Evidence map›Paper›PMID 36297391›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Development of Capsaicin-Containing Analgesic Silicone-Based Transdermal Patches.

Szabolcs László, István Z Bátai, Szilvia Berkó, Erzsébet Csányi, Ágnes Dombi, Gábor Pozsgai, Kata Bölcskei, Lajos Botz, Ödön Wagner, Erika Pintér

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Combining Ability ofCurrent issues in molecular biology · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Szabolcs LászlóDepartment of Inorganic and Analytical Chemistry, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.
István Z BátaiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti u. 12, H-7624 Pécs, Hungary.
Szilvia BerkóInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.ORCID 0000-0002-3842-8876
Erzsébet CsányiInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.ORCID 0000-0002-3010-1959
Ágnes DombiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti u. 12, H-7624 Pécs, Hungary.
Gábor PozsgaiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti u. 12, H-7624 Pécs, Hungary.
Kata BölcskeiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti u. 12, H-7624 Pécs, Hungary.
Lajos BotzDepartment of Pharmaceutics and Central Clinical Pharmacy, Faculty of Pharmacy, University of Pécs, Honvéd u. 3., H-7624 Pécs, Hungary.
Ödön WagnerDepartment of Inorganic and Analytical Chemistry, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Erika PintérDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti u. 12, H-7624 Pécs, Hungary.ORCID 0000-0001-9898-632X
University of Pecs · HUBudapest University of Technology and Economics · HUUniversity of Szeged · HU

Funding

National Research, Development and Innovation Fund of Hungary TKP2021-EGA-13National Research, Development and Innovation Office OTKA FK 132454National Research, Development and Innovation Office OTKA K 134214
6 · The paper itself

Abstract

Transdermal therapeutic systems (TTSs) enable convenient dosing in drug therapy. Modified silicone-polymer-based patches are well-controlled and cost-effective matrix diffusion systems. In the present study, we investigated the substance release properties, skin penetration, and analgesic effect of this type of TTS loaded with low-dose capsaicin. Release properties were measured in Franz diffusion cell and continuous flow-through cell approaches. Capsaicin was detected with HPLC-UV and UV spectrophotometry. Raman spectroscopy was conducted on human skin samples exposed to the TTS. A surgical incision or carrageenan injection was performed on one hind paw of male Wistar rats. TTSs were applied to the epilated dorsal skin. Patches were kept on the animals for 6 h. The thermal hyperalgesia and mechanical pain threshold of the hind paws were detected. Patches exhibited controlled, zero-order kinetic capsaicin release. According to the Raman mapping, capsaicin penetrated into the epidermis and dermis of human skin, where the target receptors are expressed. The thermal pain threshold drop of the operated rat paws was reversed by capsaicin treatment compared to that of animals treated with control patches. It was concluded that our modified silicone-polymer-based capsaicin-containing TTS is suitable for the relief of traumatic and inflammatory pain.

Indexed as

addition polymercapsaicinsiliconetransdermal therapeutic system

Identifiers

PMID36297391
PMCPMC9611826
OpenAlexW4306764918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.