Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 7 institutions in 5 countries.
Joyce E GutiérrezLaboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos 1041-A, Caracas 47206, Venezuela.
Esteban Fernandez-MoreiraEscuela de Medicina UEES, Universidad Espíritu Santo, Samborondón 092301, Ecuador.
Miguel A RodríguezLaboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos 1041-A, Caracas 47206, Venezuela.
Michael R MijaresUnidad de Biotecnología, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos 1041-A, Caracas 47206, Venezuela.ORCID 0000-0002-0055-2804
Juan Bautista De SanctisInstituto de Immunologia, Facultad de Medicina, Universidad Central de Venezuela, Los Chaguaramos 1050-A, Caracas 50109, Venezuela.ORCID 0000-0002-5480-4608
Soňa GurskáInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Advanced Technology and Research Institute, Palacky University, Hněvotínská 1333/5, 77900 Olomouc, Czech Republic.
Petr DžubákInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Advanced Technology and Research Institute, Palacky University, Hněvotínská 1333/5, 77900 Olomouc, Czech Republic.ORCID 0000-0002-3098-5969
Marián HajdůchInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Advanced Technology and Research Institute, Palacky University, Hněvotínská 1333/5, 77900 Olomouc, Czech Republic.ORCID 0000-0002-4834-908X
Julia Bruno-ColmenarezDepartment of Chemical and Environmental Science, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0001-9476-7189
Luis RojasLaboratorio de Productos Naturales, Facultad de Farmacia y Bioanálisis, Universidad de Los Andes, Merida 5101, Venezuela.
Denis DeffieuxInstitut des Sciences Moléculaires, Université de Bordeaux (UMR-CNRS 5255), 351 Cours de la Libération, CEDEX, 33405 Talence, France.
Laurent PouységuInstitut des Sciences Moléculaires, Université de Bordeaux (UMR-CNRS 5255), 351 Cours de la Libération, CEDEX, 33405 Talence, France.
Stéphane QuideauInstitut des Sciences Moléculaires, Université de Bordeaux (UMR-CNRS 5255), 351 Cours de la Libération, CEDEX, 33405 Talence, France.ORCID 0000-0002-7079-9757
Jaime CharrisLaboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Los Chaguaramos 1041-A, Caracas 47206, Venezuela.ORCID 0000-0003-4404-2619
Hegira RamírezDirección de Investigación, Universidad ECOTEC, Km. 13.5 Vía Samborondón, Guayaquil 092302, Ecuador.ORCID 0000-0003-1916-6118
Central University of Venezuela · VEInstitute of Molecular and Translational Medicine · CZCentre National de la Recherche Scientifique · FRUniversidad de Especialidades Espíritu Santo · ECUniversidad Ecotec · ECUniversity of Limerick · IEUniversity of the Andes · VE
Funding
Escuela de Medicina UES 2022-MED-001the Czech Ministry of Education, Youth and Sports CZ-OPENSCREEN-LM2018130, and EATRIS-CZ-LM2018133The France-Venezuela PCP program 2013000438
6 · The paper itself
Abstract
A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl
Indexed as
antiproliferative activitycell cycleDNA/RNA damageSulfanyl-Sulfinyl-Sulfonyl groupssynthesis of 4-thioalkylquinoline
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage. · full record | OpenQuestion