Evidence map›Paper›PMID 36297330›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese

I-Wen Lo, Geng-You Liao, Jin-Ching Lee, Chi-I Chang, Yang-Chang Wu, Yen-Yu Chen, Shang-Pin Liu, Huey-Jen Su, Chih-I Liu, Chia-Yi Kuo and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

I-Wen LoGenomics Research Center, Academia Sinica, Taipei 115201, Taiwan.ORCID 0000-0002-7461-9311
Geng-You LiaoInstitute of Physiology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Jin-Ching LeeDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.ORCID 0000-0003-0729-9589
Chi-I ChangDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.
Yang-Chang WuChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404332, Taiwan.
Yen-Yu ChenDepartment of Education and Research, Taipei City Hospital, Taipei 103212, Taiwan.
Shang-Pin LiuBachelor of Program in Scientific Agriculture, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.
Huey-Jen SuDepartment of Nursing, Meiho University, Pingtung 912009, Taiwan.
Chih-I LiuDepartment of Nursing, Meiho University, Pingtung 912009, Taiwan.
Chia-Yi KuoDepartment of Biological Science and Technology, Meiho University, Pingtung 912009, Taiwan.
Zheng-Yu LinDepartment of Biological Science and Technology, Meiho University, Pingtung 912009, Taiwan.
Tsung-Lin LiGenomics Research Center, Academia Sinica, Taipei 115201, Taiwan.ORCID 0000-0002-9739-9761
Yun-Sheng LinDepartment of Biological Science and Technology, Meiho University, Pingtung 912009, Taiwan.
Chia-Ching LiawDivision of Chinese Material Medica Development, National Research Institute of Chinese Medicine, Taipei 112026, Taiwan.ORCID 0000-0001-5642-4679
Meiho University · TWGenomics Research Center, Academia Sinica · TWNational Pingtung University of Science and Technology · TWChina Medical University · TWNational Chiayi University · TWNational Sun Yat-sen University · TWNational Yang Ming Chiao Tung University · TWTaipei City Hospital · TW

Funding

Ministry of Science and Technology, Republic of China MOST 107-2320-B-276-001
6 · The paper itself

Abstract

Hybrid natural products produced via mixed biosynthetic pathways are unique and often surprise one with unexpected medicinal properties in addition to their fascinating structural complexity/diversity. In view of chemical structures, hybridization is a way of diversifying natural products usually through dimerization of two similar or dissimilar subcomponents through a C-C or N-C covalent linkage. Here, we report four structurally attractive diterpene-alkaloid conjugates polyalongarins A-D (

Indexed as

anti-DENV2aporphineclerodaneNS2B-NS3 proteasePolyalthia longifolia var. pendulaproaporphine

Identifiers

PMID36297330
PMCPMC9610793
OpenAlexW4303962432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.