Evidence map›Paper›PMID 36297038›Full record

ArticleNutrients2022

Effect of

Jun Heo, Minsun Kim, Jae-Hyun Kim, Hwajeong Shin, Seo-Eun Lim, Hyuk-Sang Jung, Youngjoo Sohn, Jaseung Ku

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. The Role of Dandelion (Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jun HeoDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Minsun KimDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Jae-Hyun KimDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Hwajeong ShinDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Seo-Eun LimDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Hyuk-Sang JungDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.ORCID 0000-0002-7256-9672
Youngjoo SohnDepartment of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Jaseung KuBogwang Korean Medical Clinic 236, Gucheonmyeon-ro, Gangdong-gu, Seoul 05334, Korea.
Kyung Hee University · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education 2021R1A6A3A1303978212National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) 2020R1A2C1007836
6 · The paper itself

Abstract

Bone is a dynamic tissue that maintains homeostasis with a balance of osteoclasts for bone resorption and osteoblasts for bone formation. Women are deficient in estrogen after menopause, which promotes bone resorption due to excessive activity of osteoclasts, leading to osteoporosis. TH (also known as dandelion) is native to warm regions and has traditionally been used to treat gynecological diseases and inflammation. Menopause is a major cause of osteoporosis as it causes abnormal activity of osteoclasts, and various studies have shown that anti-inflammatory drugs have the potential to treat osteoporosis. We analyzed the effect of TH on osteoclast differentiation and the relevant mechanisms using RANKL. After administration of TH in a menopause-like rat model in which ovariectomy of the was rats carried out, changes in bone microstructure were analyzed via micro-CT, and the antiosteoporosis effect of TH was verified by a histological analysis. In addition, the pharmacological effects of TH in an animal model of osteoporosis were compared and analyzed with osteoporosis medications (17β-estradiol (E

Indexed as

Bone ResorptionOsteoporosisAlendronateAnimalsAnti-Inflammatory AgentsCell DifferentiationEstradiolEstrogensFemaleHumansOsteoclastsOsteogenesisOvariectomyRANK LigandRatsAlendronateAnti-Inflammatory AgentsEstradiolEstrogensRANK Ligandc-FosNFATc1osteoclastovariectomizedRANKLTaraxaci Herba

Identifiers

PMID36297038
PMCPMC9609713
OpenAlexW4306761538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.