Evidence map›Paper›PMID 36296981›Full record

ReviewNutrients2022

Evolving Concepts on Inflammatory Biomarkers and Malnutrition in Chronic Kidney Disease.

Fredzzia Graterol Torres, María Molina, Jordi Soler-Majoral, Gregorio Romero-González, Néstor Rodríguez Chitiva, Maribel Troya-Saborido, Guillem Socias Rullan, Elena Burgos, Javier Paúl Martínez, Marina Urrutia Jou and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Fredzzia Graterol TorresNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
María MolinaNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.ORCID 0000-0003-0033-4214
Jordi Soler-MajoralNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Gregorio Romero-GonzálezNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.ORCID 0000-0001-7481-3678
Néstor Rodríguez ChitivaNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Maribel Troya-SaboridoNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Guillem Socias RullanEndocrinology and Nutrition Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Elena BurgosNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Javier Paúl MartínezNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Marina Urrutia JouNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Carles CañamerasNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Josep Riera SadurníNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Anna VilaNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.
Jordi BoverNephrology Department, University Hospital Germans Trias i Pujol (HGTiP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, Spain.ORCID 0000-0003-3577-2273
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESUniversitat Autònoma de Barcelona · ESHospital Universitari Germans Trias i Pujol · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While patient care, kidney replacement therapy, and transplantation techniques for chronic kidney disease (CKD) have continued to progress, the incidence of malnutrition disorders in CKD appears to have remained unchanged over time. However, there is now a better understanding of the underlying pathophysiology according to the disease background, disease stage, and the treatment received. In CKD patients, the increased production of proinflammatory cytokines and oxidative stress lead to a proinflammatory milieu that is at least partially responsible for the increased morbidity and mortality in this patient population. New insights into the pathogenic role of innate immunity and the proinflammatory cytokine profile, characterized, for instance, by higher levels of IL-6 and TNF-α, explain some of the clinical and laboratory abnormalities observed in these patients. In this article, we will explore currently available nutritional-inflammatory biomarkers in distinct CKD populations (hemodialysis, peritoneal dialysis, transplantation) with a view to evaluating their efficacy as predictors of malnutrition and their involvement in the common proinflammatory process. Although there is a direct relationship between inflammatory-nutritional status, signs and symptoms [e.g., protein-energy wasting (PEW), anorexia], and comorbidities (e.g., atheromatosis, atherosclerosis), we are in need of clearly standardized markers for nutritional-inflammatory assessment to improve their performance and design appropriate bidirectional interventions.

Indexed as

Kidney Failure, ChronicMalnutritionProtein-Energy MalnutritionRenal Insufficiency, ChronicBiomarkersHumansInterleukin-6Nutritional StatusRenal DialysisTumor Necrosis Factor-alphaBiomarkersInterleukin-6Tumor Necrosis Factor-alphachronic kidney diseaseCKDcytokinesinflammationmalnutritionmalnutrition inflammation cachexia syndromemalnutrition-inflammation scoreMICSMISproinflammatory cytokinesprotein-energy wastingsarcopenia

Identifiers

PMID36296981
PMCPMC9611115
OpenAlexW4306398944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.