ArticleNutrients2022
Dietary Fats and Cardio-Metabolic Outcomes in a Cohort of Italian Adults.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
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- The relationship between polyunsaturated fatty acids and inflammation: evidence from cohort and Mendelian randomization analyses.International journal of epidemiology · 2025Article
- Dairy-derived saturated fats were not associated with risk of type 2 diabetes mellitus and metabolic syndrome: Tehran Lipid and Glucose Study.Diabetology & metabolic syndrome · 2025Article
- Serum Medium-Chain Fatty Acids and the Risk of Incident Diabetes: Findings From the 4C Study.The Journal of clinical endocrinology and metabolism · 2025Article
- The triglyceride-glucose index, metabolic biomarkers, and olive oil in diabetic patients: Real-world evidence from a propensity-score matched study.Clinics (Sao Paulo, Brazil) · 2025Article
- High Meat Intake and Ferritin Levels in Relation to Cardiovascular Risk Among Individuals with Diabetes in Mongolia.Nutrients · 2024Article
- The association between dietary quality index- international and metabolic risk factors in RaNCD cohort study.BMC public health · 2024Article
- Association of plant-based diet indexes with the metabolomic profile.Scientific reports · 2024Article
- The relationship between fermented and nonfermented dairy products consumption and hypertension among premature coronary artery disease patients: Iran premature coronary artery disease study.Food science & nutrition · 2024Article
- Quality assessment of flax advanced breeding lines varying in seed coat color and their potential use in the food and industrial applications.BMC plant biology · 2024Article
- Article
- Dietary Fats and Cognitive Status in Italian Middle-Old Adults.Nutrients · 2023Article
- Dietary Fats and Depressive Symptoms in Italian Adults.Nutrients · 2023Article
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
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- Association between Intake of Fermented Dairy Product and Diet Quality, Health Beliefs in a Representative Sample of Polish Population.Nutrients · 2022Article
- A comparison of principal component analysis, partial least-squares, and reduced-rank regressions in the identification of dietary patterns associated with hypertension: YaHS-TAMYZ and Shahedieh cohort studies.Frontiers in nutrition · 2022Article
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8 authors at 4 institutions in 2 countries.
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Abstract
backgroundDietary fats, and especially saturated fatty acid (SFA), have been blamed for being the culprit in the dramatic increase in obesity and its associated diseases. However multiple systematic reviews and recent meta-analyses do not support the association between SFA and cardiovascular diseases. Thus, the objective of this study was to test whether specific types and subtypes of dietary fats are associated with metabolic outcomes in a cohort of Italian adults.
methodsNutritional and demographic data of 1936 adults living in the south of Italy were examined. Food frequency questionnaires (FFQs) were administered to assess the intake of total dietary fat and each specific class of dietary fat, such as SFA, monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA). The intake of fatty acids was also examined according to the carbon-chain length of each individual class. Cases of hypertension, type-2 diabetes and dyslipidemias were collected from previous doctor-confirmed diagnosis records (or direct measurement of blood pressure).
resultsAfter adjustment for potential confounding factors, individuals reporting higher intakes of total and saturated fats were associated with lower likelihood of having hypertension (odds ratio (OR) = 0.57, 95% CI: 0.35, 0.91 and OR = 0.55, 95% CI: 0.34, 0.89, respectively). Moreover, higher intake of short-chain saturated fatty acids (SCSFAs) and medium-chain saturated fatty acids (MCSFAs) was inversely associated with dyslipidemia and diabetes (OR = 0.43, 95% CI: 0.23, 0.82 and OR = 0.25, 95% CI: 0.09, 0.72, respectively). Among MUFAs, C18:1 was inversely associated with hypertension and diabetes (OR = 0.52, 95% CI: 0.30, 0.92 and OR = 0.21, 95% CI: 0.07, 0.67, respectively), while C14:1 intake was inversely associated only with hypertension (OR = 0.57, 95% CI: 0.37, 0.88). In contrast, C20:1 intake was associated with dyslipidemia (OR = 3.35, 95% CI: 1.33, 8.42). Regarding PUFA, C18:2 and 20:5 were inversely associated with hypertension (OR = 0.33, 95% CI: 0.18, 0.60 and OR = 0.30, 95% CI: 0.10, 0.89, respectively).
conclusionsThe consumption of SFA does not seem to be harmful to cardio-metabolic health and, on the contrary, SCSFA may exert beneficial effects. Further studies are needed to clearly validate the results of the present study.
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