Evidence map›Paper›PMID 36296914›Full record

ReviewNutrients2022

Relationship between Maternal Vitamin D Levels and Adverse Outcomes.

Heng Zhang, Shumin Wang, Lingjin Tuo, Qixiao Zhai, Jingjing Cui, Daozhen Chen, Dexiang Xu

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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  20. Vitamin D and Intrauterine Growth Restriction (IUGR).International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Heng ZhangDepartment of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi 214002, China.
Shumin WangSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Lingjin TuoDepartment of Toxicology, Anhui Medical University, Hefei 230032, China.
Qixiao ZhaiSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-0605-2675
Jingjing CuiWuxi School of Medicine, Jiangnan University, Wuxi 214002, China.
Daozhen ChenDepartment of Clinical Laboratory, Wuxi Maternity and Child Health Care Hospital, Wuxi 214002, China.
Dexiang XuDepartment of Toxicology, Anhui Medical University, Hefei 230032, China.ORCID 0000-0002-5126-4335
Jiangnan University · CNAnhui Medical University · CNWuhan Wudong Hospital · CN

Funding

National Natural Science Foundation of China 81502813
6 · The paper itself

Abstract

Vitamin D (VD), a fat-soluble vitamin, has a variety of functions that are important for growth and development, including regulation of cell differentiation and apoptosis, immune system development, and brain development. As such, VD status during pregnancy is critical for maternal health, fetal skeletal growth, and optimal pregnancy outcomes. Studies have confirmed that adverse pregnancy outcomes, such as preeclampsia, low birth weight, neonatal hypocalcemia, poor postnatal growth, skeletal fragility, and increased incidence of autoimmune diseases, can be associated with low VD levels during pregnancy and infancy. Thus, there is growing interest in the role of VD during pregnancy. This review summarizes the potential adverse health outcomes of maternal VD status during pregnancy for both mother and offspring (gestational diabetes mellitus, hypertensive gestational hypertension, intrauterine growth restriction, miscarriage, stillbirth, and preterm birth) and discusses the underlying mechanisms (regulation of cytokine pathways, immune system processing, internal secretion, placental function, etc.) of VD in regulating each of the outcomes. This review aims to provide a basis for public health intervention strategies to reduce the incidence of adverse pregnancies.

Indexed as

Pregnancy ComplicationsPremature BirthVitamin D DeficiencyCytokinesFemaleHumansInfant, NewbornPlacentaPregnancyPregnancy OutcomeVitamin DVitaminsCytokinesVitamin DVitaminsadverse outcomesmechanismspregnancyvitamin D

Identifiers

PMID36296914
PMCPMC9610169
OpenAlexW4304775387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.