Evidence map›Paper›PMID 36296909›Full record

ReviewNutrients2022

Fetal Alcohol Spectrum Disorder and Iron Homeostasis.

Regan Bradley, Koffi L Lakpa, Michael Burd, Sunil Mehta, Maja Z Katusic, Jacob R Greenmyer

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The Autism Spectrum Disorder and Its Possible Origins in Pregnancy.International journal of environmental research and public health · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Regan BradleySchool of Medicine, University of North Dakota, Grand Forks, ND 58201, USA.ORCID 0000-0002-5314-3158
Koffi L LakpaSchool of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
Michael BurdSchool of Medicine, University of North Dakota, Grand Forks, ND 58201, USA.
Sunil MehtaMayo Clinic, Developmental and Behavioral Pediatrics, Psychiatry and Psychology, Rochester, MN 55905, USA.
Maja Z KatusicMayo Clinic, Pediatric and Adolescent Medicine, Rochester, MN 55905, USA.
Jacob R GreenmyerMayo Clinic, Pediatric and Adolescent Medicine, Rochester, MN 55905, USA.
Mayo Clinic in Florida · USUniversity of North Dakota · USMayo Clinic in Arizona · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD presents with significant phenotypic variability and may be modified by gestational variables such as maternal nutritional status. Iron serves a critical function in the development of and processes within central nervous system (CNS) structures. Gestational iron deficiency alters CNS development and may contribute to neurodevelopmental impairment in FASD. This review explores the relationship between iron deficiency and fetal alcohol spectrum disorder as described in small animal and human studies. Consideration is given to the pathophysiologic mechanisms linking iron homeostasis and prenatal alcohol exposure. Existing data suggest that iron deficiency contributes to the severity of FASD and provide a mechanistic explanation linking these two conditions.

Indexed as

Fetal Alcohol Spectrum DisordersIron DeficienciesPrenatal Exposure Delayed EffectsAlcohol DrinkingAnimalsFemaleHomeostasisHumansIronPregnancyIronfetal alcohol spectrum disordersiron deficiencyiron supplementationmaternal/fetal anemiamaternal/fetal nutritionpregnancyprenatal alcohol exposure

Identifiers

PMID36296909
PMCPMC9607572
OpenAlexW4304630383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.