Evidence map›Paper›PMID 36296907›Full record

ArticleNutrients2022

C Alejandra Monraz-Méndez, Rebeca Escutia-Gutiérrez, Jonathan Samael Rodriguez-Sanabria, Marina Galicia-Moreno, Hugo Christian Monroy-Ramírez, Laura Sánchez-Orozco, Jesus García-Bañuelos, Ricardo De la Rosa-Bibiano, Arturo Santos, Juan Armendáriz-Borunda and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. FermentedPharmaceutical biology · 2026
    Article
  2. Article
  3. Human miRNAs in Cancer: Statistical Trends and Cross Kingdom Approach.International journal of molecular sciences · 2025
    Article
  4. Article
  5. Synergistic Beneficial Effects of Flaxseed (Food science & nutrition · 2025
    Review
  6. Review
  7. Effects ofJournal of nutrition and metabolism · 2024
    Review
  8. Promising Influences ofEndocrine, metabolic & immune disorders drug targets · 2024
    Review
  9. Article
  10. A Review on the Neuroprotective Effect ofOxidative medicine and cellular longevity · 2024
    Review
  11. Effect ofAquaculture nutrition · 2024
    Article
  12. Micro-Executor of Natural Products in Metabolic Diseases.Molecules (Basel, Switzerland) · 2023
    Review
  13. Journal of experimental pharmacology · 2023
    Article
  14. Metabolites ofMetabolites · 2022
    Article
  15. Nutrients · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

C Alejandra Monraz-MéndezInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Rebeca Escutia-GutiérrezInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-6615-4251
Jonathan Samael Rodriguez-SanabriaInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Marina Galicia-MorenoInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-7435-1861
Hugo Christian Monroy-RamírezInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Laura Sánchez-OrozcoInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Jesus García-BañuelosInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-3430-9391
Ricardo De la Rosa-BibianoInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-6252-1739
Arturo SantosTecnologico de Monterrey, Escuela de Medicina, Monterrey 64849, Nuevo Leon, Mexico.ORCID 0000-0003-4640-7263
Juan Armendáriz-BorundaInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-7101-9943
Ana Sandoval-RodríguezInstitute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-1708-1495

Funding

University of Guadalajara Fortalecimiento 2021
6 · The paper itself

Abstract

BACKGROUND AND

aimsMetabolic Associated Fatty Liver Disease (MAFLD) encompasses a spectrum of diseases from simple steatosis to nonalcoholic steatohepatitis (NASH). Here, we investigated the hepatoprotective role of

methodsMale C57BL/6J mice were fed with a high fat diet (HFD, 60% lipids, 42 gr/L sugar in water) for 16 weeks. Moringa extract was administered via gavage during the final 8 weeks. Insulin Tolerance Test (ITT) and HOMA-IR were calculated. Serum levels of insulin, resistin, leptin and PAI-1 and hepatic expression of

resultsAnimals treated with Moringa extract improved ITT and decreased SREBP1c hepatic protein, while SIRT1 increased. Hepatic expression of

conclusionsMoringa prevented progression of liver damage in a model of NASH and improved biochemical, histological and hepatic expression of genes and miRNAs implicated in MAFLD/NASH development.

Indexed as

Insulin ResistanceMicroRNAsMoringa oleiferaNon-alcoholic Fatty Liver DiseasePlant ExtractsAnimalsDiet, High-FatEpigenesis, GeneticInsulinLeptinLipidsLiverMaleMiceMice, Inbred C57BLPlasminogen Activator Inhibitor 1InsulinLeptinLipidsMicroRNAsPlant ExtractsPlasminogen Activator Inhibitor 1ResistinSirtuin 1Sterol Regulatory Element Binding Protein 1epigeneticsliverMAFLDmicroarraysmiRNAsMoringa

Identifiers

PMID36296907
PMCPMC9611907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.