Dietary Hempseed Decreases Femur Maximum Load in a Young Female C57BL/6 Mouse Model but Does Not Influence Bone Mineral Density or Micro-Architecture.

Chandler A Sparks, Hailey M Streff, Derrick W Williams, Cynthia A Blanton, Annette M Gabaldón

Abstract read

In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chandler A SparksHackensack Meridian School of Medicine, Nutley, NJ 07110, USA.ORCID 0000-0002-1490-1905

Hailey M StreffCollege of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Derrick W WilliamsHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3414-2405

Cynthia A BlantonDepartment of Nutrition and Dietetics, Idaho State University, Pocatello, ID 83209, USA.ORCID 0000-0002-5442-1842

Annette M GabaldónDepartment of Biology, Colorado State University-Pueblo, Pueblo, CO 81001, USA.

Funding

Institute of Cannabis Research NA

6 · The paper itself

Abstract

Numerous seed and seed extract diets have been investigated as a means of combating age-related bone loss, with many findings suggesting that the seeds/extracts confer positive effects on bone. Recently, there has been rising interest in the use of dietary hempseed in human and animal diets due to a perceived health benefit from the seed. Despite this, there has been a lack of research investigating the physiologic effects of dietary hempseed on bone. Previous studies have suggested that hempseed may enhance bone strength. However, a complete understanding of the effects of hempseed on bone mineralization, bone micro-architecture, and bone biomechanical properties is lacking. Using a young and developing female C57BL/6 mouse model, we aimed to fill these gaps in knowledge. From five to twenty-nine weeks of age, the mice were raised on either a control (0%), 50 g/kg (5%), or 150 g/kg (15%) hempseed diet (

Indexed as

Bone DensityFemurAnimalsDietFemaleHumansMiceMice, Inbred C57BLPlant ExtractsPlant ExtractsantinutrientsbiomechanicsboneC57BL/6 micehempseed

Identifiers

PMID36296906

DOI10.3390/nu14204224

PMCPMC9607594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.