Evidence map›Paper›PMID 36296708›Full record

ArticleMolecules (Basel, Switzerland)2022

Bioanalytical Method Development, Validation and Stability Assessment of Xanthohumol in Rat Plasma.

Vancha Harish, Waleed Hassan Almalki, Ahmed Alshehri, Abdulaziz Alzahrani, Sami I Alzarea, Imran Kazmi, Monica Gulati, Devesh Tewari, Dinesh Kumar Chellappan, Gaurav Gupta and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Antioxidant Constituents of Hops (Materials (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 4 countries.

Vancha HarishSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, Punjab, India.ORCID 0000-0003-3651-0662
Waleed Hassan AlmalkiDepartment of Pharmacology, Umm Al-Qura College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Ahmed AlshehriDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
Abdulaziz AlzahraniPharmaceuticals Chemistry Department, Faculty of Clinical Pharmacy, Al Baha University, Al Baha 65779, Saudi Arabia.
Sami I AlzareaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
Imran KazmiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-1881-5219
Monica GulatiSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, Punjab, India.
Devesh TewariDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, Delhi, India.ORCID 0000-0002-5125-3791
Dinesh Kumar ChellappanSchool of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.ORCID 0000-0001-5567-6663
Gaurav GuptaSchool of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur 302017, Rajasthan, India.
Kamal DuaFaculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.ORCID 0000-0002-7507-1159
Sachin Kumar SinghSchool of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara 144411, Punjab, India.ORCID 0000-0003-3823-6572
Lovely Professional University · INAl Baha University · SADelhi Pharmaceutical Science and Research University · INIMU University · MYJouf University · SAKing Abdulaziz University · SANorthern Border University · SAUmm al-Qura University · SAUniversity of Technology Sydney · AUUttaranchal University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xanthohumol (XH) a prenylated chalcone has diverse therapeutic effects against various diseases. In the present study, a bioanalytical method was developed for XH in rat plasma using reverse phase high performance liquid chromatography. The validation of the method was performed as per ICH M10 guidelines using curcumin as an internal standard. The Isocratic elution method was used with a run time of 10 min, wherein the mobile phase ratio 0.1%

Indexed as

ChalconesCurcuminAnimalsChromatography, High Pressure LiquidMethanolRatsReproducibility of ResultsChalconesCurcuminMethanolbioanalytical methodrat-plasmaRP-HPLCstabilityxanthohumol

Identifiers

PMID36296708
PMCPMC9608944
OpenAlexW4307265265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.