Evidence map›Paper›PMID 36296692›Full record

ArticleMolecules (Basel, Switzerland)2022

Anticholinesterase Activity of Selected Medicinal Plants from Navarra Region of Spain and a Detailed Phytochemical Investigation of

María Pilar de Torre, Rita Yolanda Cavero, María Isabel Calvo

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Antitumor Alkaloids in Tibetan Corydalis: Chemical Diversity and Pharmacological Insights.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  6. Review
  7. International journal of molecular sciences · 2023
    Article
  8. Biomolecular Screening ofMolecules (Basel, Switzerland) · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

María Pilar de TorreDepartment of Pharmaceutical Technology and Chemical, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea s/n, 31008 Pamplona, Spain.ORCID 0000-0002-1112-344X
Rita Yolanda CaveroDepartment of Environmental Biology, Faculty of Sciences, University of Navarra, Irunlarrea s/n, 31008 Pamplona, Spain.ORCID 0000-0002-8106-3243
María Isabel CalvoDepartment of Pharmaceutical Technology and Chemical, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea s/n, 31008 Pamplona, Spain.ORCID 0000-0002-3159-0336
Navarre Institute of Health Research · ESUniversidad de Navarra · ES

Funding

PIUNA (Plan Investigador de la Universidad de Navarra) PIUNA/2018
6 · The paper itself

Abstract

Alzheimer's disease is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment due to a severe loss of cholinergic neurons in specific brain areas. It is the most common type of dementia in the aging population. Although many anti-acetylcholinesterase (AChE) drugs are already available on the market, their performance sometimes yields unexpected results. For this reason, research works are ongoing to find potential anti-AChE agents both from natural and synthetic sources. In this study, 90 extracts from 30 native and naturalized medicinal plants are tested by TLC and Ellman's colorimetric assay at 250, 125 and 62.5 μg/mL in order to determine the inhibitory effect on AChE. In total, 21 out of 90 extracts show high anti-AChE activity (75-100% inhibition) in a dose-dependent manner. Among them, ethanolic extract from aerial parts of

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesOriganumPlants, MedicinalAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsFlavonoidsGalantaminePhenolsPhytochemicalsPlant ExtractsSpainAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsFlavonoidsGalantaminePhenolsPhytochemicalsPlant ExtractsAlzheimerchromatographyethnopharmacologyoreganophenolic compoundssyringic acids

Identifiers

PMID36296692
PMCPMC9610729
OpenAlexW4306936858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.