Evidence map›Paper›PMID 36296673›Full record

ReviewMolecules (Basel, Switzerland)2022

Natural Compounds and Products from an Anti-Aging Perspective.

Geir Bjørklund, Mariia Shanaida, Roman Lysiuk, Monica Butnariu, Massimiliano Peana, Ioan Sarac, Oksana Strus, Kateryna Smetanina, Salvatore Chirumbolo

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.

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  13. The selenium-enrichedFrontiers in microbiology · 2026
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  18. Evaluation of antioxidant and anti-inflammatory potential andJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Geir BjørklundCouncil for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610 Mo i Rana, Norway.ORCID 0000-0003-2632-3935
Mariia ShanaidaDepartment of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.ORCID 0000-0003-1070-6739
Roman LysiukDepartment of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine.ORCID 0000-0003-0961-2970
Monica ButnariuChemistry & Biochemistry Discipline, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, 300645 Timisoara, Romania.ORCID 0000-0002-2032-5000
Massimiliano PeanaDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3306-0419
Ioan SaracChemistry & Biochemistry Discipline, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, 300645 Timisoara, Romania.
Oksana StrusDepartment of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine.
Kateryna SmetaninaDepartment of Organic Chemistry and Pharmacy, Lesya Ukrainka Volyn National University, 43025 Lutsk, Ukraine.ORCID 0000-0003-0040-2096
Salvatore ChirumboloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-1789-8307
Danylo Halytsky Lviv National Medical University · UAWest University of Timişoara · ROI.Horbachevsky Ternopil National Medical University · UALesya Ukrainka Volyn National University · UAThe Research Council of Norway · NOUniversity of Sassari · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a very complex process that is accompanied by a degenerative impairment in many of the major functions of the human body over time. This inevitable process is influenced by hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, and so on. Many external and internal signs and symptoms are related with the aging process and senescence, including skin dryness and wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, a consequence of the imbalance between pro- and antioxidants, is one of the main provoking factors causing aging-related damages and concerns, due to the generation of highly reactive byproducts such as reactive oxygen and nitrogen species during the metabolism, which result in cellular damage and apoptosis. Antioxidants can prevent these processes and extend healthy longevity due to the ability to inhibit the formation of free radicals or interrupt their propagation, thereby lowering the level of oxidative stress. This review focuses on supporting the antioxidant system of the organism by balancing the diet through the consumption of the necessary amount of natural ingredients, including vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants' fibers, nutritional supplements, polyphenols, some phytoextracts, and drinking water.

Indexed as

AntioxidantsDrinking WaterAgingAmino Acids, EssentialFatty Acids, UnsaturatedFree RadicalsHumansMineralsNitrogenOxidative StressOxygenReactive Oxygen SpeciesVitaminsXenobioticsAmino Acids, EssentialAntioxidantsDrinking WaterFatty Acids, UnsaturatedFree RadicalsMineralsNitrogenOxygenReactive Oxygen SpeciesVitaminsXenobioticsagingantioxidantscosmetic ingredientsmedicinal plantsnatural compoundsoxidative stressprobiotics

Identifiers

PMID36296673
PMCPMC9610014
OpenAlexW4306936876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.