Evidence map›Paper›PMID 36296656›Full record

ArticleMolecules (Basel, Switzerland)2022

Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies.

Matteo Rossi Sebastiano, Giuseppe Ermondi, Kai Sato, Asako Otomo, Shinji Hadano, Giulia Caron

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Drug repurposing in hereditary ataxia.npj drug discovery · 2026
    Review
  2. MK4 Repositioning for IAHSP: OvercomingACS chemical neuroscience · 2026
    Article
  3. Hereditary spastic paraplegia: from decades of therapy to future innovations.Therapeutic advances in neurological disorders · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Matteo Rossi SebastianoMolecular Biotechnology and Health Sciences Department, University of Torino, Quarello 15, 10135 Torino, Italy.ORCID 0000-0002-9925-1904
Giuseppe ErmondiMolecular Biotechnology and Health Sciences Department, University of Torino, Quarello 15, 10135 Torino, Italy.
Kai SatoMolecular Neuropathobiology Laboratory, Department of Molecular Life Sciences, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Asako OtomoMolecular Neuropathobiology Laboratory, Department of Molecular Life Sciences, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Shinji HadanoMolecular Neuropathobiology Laboratory, Department of Molecular Life Sciences, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0002-4997-3968
Giulia CaronMolecular Biotechnology and Health Sciences Department, University of Torino, Quarello 15, 10135 Torino, Italy.
Tokai University · JPUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infantile onset hereditary spastic paralysis (IAHSP) is a rare neurological disease diagnosed in less than 50 children worldwide. It is transmitted with a recessive pattern and originates from mutations of the

Indexed as

LysineTryptophanAmyotrophic Lateral SclerosisArginineChildGuanine Nucleotide Exchange FactorsHeLa CellsHumansMuscle SpasticityMutationParalysisPrecision MedicineSpastic Paraplegia, HereditaryArginineGuanine Nucleotide Exchange FactorsLysineTryptophanALS2drug repurposinginfantile onset ascending hereditary spastic paralysispersonalized medicinevirtual screeningvitamin K

Identifiers

PMID36296656
PMCPMC9609931
OpenAlexW4306835854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.