Evidence map›Paper›PMID 36296646›Full record

ReviewMolecules (Basel, Switzerland)2022

Important Hormones Regulating Lipid Metabolism.

Dengke Zhang, Yanghui Wei, Qingnan Huang, Yong Chen, Kai Zeng, Weiqin Yang, Juan Chen, Jiawei Chen

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
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  9. The Ketogenic Diet in Obesity Management: Friend or Foe?Cell biochemistry and biophysics · 2026
    Review
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  11. AnResearch square · 2026
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Dengke ZhangDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.
Yanghui WeiDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.
Qingnan HuangDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.
Yong ChenDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.
Kai ZengDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.
Weiqin YangSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.
Juan ChenDepartment of Medicine & Rehabilitation, Tung Wah Eastern Hospital, Hong Kong 200051, China.
Jiawei ChenDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.
Sun Yat-sen University · CNChinese University of Hong Kong · HK

Funding

Futian Healthcare Research Project FTWS2020079
6 · The paper itself

Abstract

There is a wide variety of kinds of lipids, and complex structures which determine the diversity and complexity of their functions. With the basic characteristic of water insolubility, lipid molecules are independent of the genetic information composed by genes to proteins, which determine the particularity of lipids in the human body, with water as the basic environment and genes to proteins as the genetic system. In this review, we have summarized the current landscape on hormone regulation of lipid metabolism. After the well-studied PI3K-AKT pathway, insulin affects fat synthesis by controlling the activity and production of various transcription factors. New mechanisms of thyroid hormone regulation are discussed, receptor α and β may mediate different procedures, the effect of thyroid hormone on mitochondria provides a new insight for hormones regulating lipid metabolism. Physiological concentration of adrenaline induces the expression of extrapituitary prolactin in adipose tissue macrophages, which promotes fat weight loss. Manipulation of hormonal action has the potential to offer a new therapeutic horizon for the global burden of obesity and its associated complications such as morbidity and mortality.

Indexed as

Lipid MetabolismProlactinAdipose TissueEpinephrineHormonesHumansInsulinLipidsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktThyroid HormonesTranscription FactorsWaterEpinephrineHormonesInsulinLipidsPhosphatidylinositol 3-KinasesProlactinProto-Oncogene Proteins c-aktThyroid HormonesTranscription FactorsWaterhormoneslipid metabolismregulation network

Identifiers

PMID36296646
PMCPMC9607181
OpenAlexW4306850104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.