Evidence map›Paper›PMID 36296595›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis and Characterization of Curcumin-Loaded Nanoparticles of Poly(Glycerol Sebacate): A Novel Highly Stable Anticancer System.

Alessio Massironi, Stefania Marzorati, Alessandra Marinelli, Marta Toccaceli, Stefano Gazzotti, Marco Aldo Ortenzi, Daniela Maggioni, Katia Petroni, Luisella Verotta

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Polymer Nanoparticles Advancements for Gynecological Cancers.International journal of nanomedicine · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessio MassironiDepartment of Environmental Science and Policy, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.ORCID 0000-0003-2946-8654
Stefania MarzoratiDepartment of Environmental Science and Policy, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.ORCID 0000-0002-9080-1973
Alessandra MarinelliDepartment of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.ORCID 0000-0002-6501-5364
Marta ToccaceliDepartment of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.ORCID 0000-0002-5897-1673
Stefano GazzottiDepartment of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.ORCID 0000-0001-5287-711X
Marco Aldo OrtenziDepartment of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.ORCID 0000-0001-6206-9589
Daniela MaggioniDepartment of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.ORCID 0000-0001-5201-4824
Katia PetroniDepartment of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.ORCID 0000-0003-3318-0442
Luisella VerottaDepartment of Environmental Science and Policy, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.ORCID 0000-0002-5739-6291

Funding

Fondazione Umberto Veronesi GRANT 2014Fondazione Umberto Veronesi GRANT to AMUniversità degli Studi di Milano PSR2020_DIP_005_PI_ACOLOUniversità degli Studi di Milano RV_PSR_SOE_2020_GDICA
6 · The paper itself

Abstract

The research for alternative administration methods for anticancer drugs, towards enhanced effectiveness and selectivity, represents a major challenge for the scientific community. In the last decade, polymeric nanostructured delivery systems represented a promising alternative to conventional drug administration since they ensure secure transport to the selected target, providing active compounds protection against elimination, while minimizing drug toxicity to non-target cells. In the present research, poly(glycerol sebacate), a biocompatible polymer, was synthesized and then nanostructured to allow curcumin encapsulation, a naturally occurring polyphenolic phytochemical isolated from the powdered rhizome of

Indexed as

Antineoplastic AgentsCurcuminNanoparticlesCell Line, TumorDecanoatesDrug CarriersGlycerolHumansParticle SizePolymersWaterAntineoplastic AgentsCurcuminDecanoatesDrug CarriersGlycerolpoly(glycerol-sebacate)PolymersWatercurcumindrug delivery systemhuman cervical cancernanoparticlespoly(glycerol sebacate)

Identifiers

PMID36296595
PMCPMC9606863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.