Evidence map›Paper›PMID 36296545›Full record

ReviewMolecules (Basel, Switzerland)2022

Mitsunobu Reaction: A Powerful Tool for the Synthesis of Natural Products: A Review.

Saba Munawar, Ameer Fawad Zahoor, Shafaqat Ali, Sadia Javed, Muhammad Irfan, Ali Irfan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. A Review of Approaches Developed for Spiroether Synthesis.Topics in current chemistry (Cham) · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Modular Enantioselective Total Syntheses of theThe Journal of organic chemistry · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saba MunawarDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Ameer Fawad ZahoorDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0003-2127-8848
Shafaqat AliCollege of Agriculture and Environmental Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0002-3773-5196
Sadia JavedDepartment of Biochemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0002-8233-5108
Muhammad IrfanDepartment of Pharmaceutics, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Ali IrfanDepartment of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.ORCID 0000-0002-8977-3303
Katarzyna Kotwica-MojzychLaboratory of Experimental Cytology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.
Mariusz MojzychDepartment of Chemistry, Siedlce University of Natural Sciences and Humanities, 3-go Maja 54, 08-110 Siedlce, Poland.ORCID 0000-0002-9884-6068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (phosphines). It is a renowned stereoselective reaction which inverts the stereochemical configuration of end products. One of the most important applications of the Mitsunobu reaction is its role in the synthesis of natural products. This review article will focus on the contribution of the Mitsunobu reaction towards the total synthesis of natural products, highlighting their biological potential during recent years.

Indexed as

Biological ProductsPhosphinesEstersOxidantsReducing AgentsBiological ProductsEstersOxidantsPhosphinesReducing Agentsalkaloidsamino acidscarbohydrateslignansMitsunobu reactionnatural productspolyketides

Identifiers

PMID36296545
PMCPMC9609662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.