ArticleMolecules (Basel, Switzerland)2022
Hydroxy-3-Phenylcoumarins as Multitarget Compounds for Skin Aging Diseases: Synthesis, Molecular Docking and Tyrosinase, Elastase, Collagenase and Hyaluronidase Inhibition, and Sun Protection Factor.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
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- Computational and Experimental Insights into Tyrosinase and Antioxidant Activities of Resveratrol and Its Derivatives: Molecular Docking, Molecular Dynamics Simulation, DFT Calculation, and In Vitro Evaluation.International journal of molecular sciences · 2025Article
- A Bioactive Emulgel Formulation ofGels (Basel, Switzerland) · 2025Article
- Structure-based design and evaluation of tyrosinase inhibitors targeting both human and mushroom isozymes.RSC medicinal chemistry · 2025Article
- In silico analysis ofNarra J · 2024Article
- Design, Synthesis, Structural Insights, Tyrosinase Inhibition, and Sun Protection Factor of New Thiosemicarbazone Derivatives.Molecules (Basel, Switzerland) · 2024Article
- Potential of Bioactive Protein and Protein Hydrolysate fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Heterocyclic Compounds as Synthetic Tyrosinase Inhibitors: Recent Advances.International journal of molecular sciences · 2023Review
- Essential Oil Compounds of Andaliman (Life (Basel, Switzerland) · 2023Article
- Coumarin-Based Compounds as Inhibitors of Tyrosinase/Tyrosine Hydroxylase: Synthesis, Kinetic Studies, and In Silico Approaches.International journal of molecular sciences · 2023Article
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
Skin aging is a progressive biological process of the human body, and it is not only time-dependent. Differently substituted 3-phenylcoumarins proved to efficiently inhibit tyrosinase. In the current work, new substitution patterns have been explored, and the biological studies were extended to other important enzymes involved in the processes of skin aging, as elastase, collagenase and hyaluronidase. From the studied series, five compounds presented inhibitory activity against tyrosinase, one compound against elastase, eight compounds against collagenase and two compounds against hyaluronidase, being five compounds dual inhibitors. The 3-(4'-Bromophenyl)-5,7-dihydroxycoumarin (
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