Evidence map›Paper›PMID 36296495›Full record

ArticleMolecules (Basel, Switzerland)2022

Cell Cycle Arrest and Apoptosis-Inducing Ability of Benzimidazole Derivatives: Design, Synthesis, Docking, and Biological Evaluation.

Syed Nazreen, Abdulraheem S A Almalki, Serag Eldin I Elbehairi, Ali A Shati, Mohammad Y Alfaifi, Ahmed A Elhenawy, Nawaf I Alsenani, Anas Alfarsi, Abdulrahman Alhadhrami, Esam A Alqurashi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Syed NazreenDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha 65799, Saudi Arabia.ORCID 0000-0002-5093-1538
Abdulraheem S A AlmalkiDepartment of Chemistry, Faculty of Science, Taif University, Taif 21974, Saudi Arabia.
Serag Eldin I ElbehairiDepartment of Biology, Faculty of Science, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0003-4680-3215
Ali A ShatiDepartment of Biology, Faculty of Science, King Khalid University, Abha 61421, Saudi Arabia.
Mohammad Y AlfaifiDepartment of Biology, Faculty of Science, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0003-4310-3539
Ahmed A ElhenawyDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha 65799, Saudi Arabia.ORCID 0000-0003-2893-0376
Nawaf I AlsenaniDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha 65799, Saudi Arabia.
Anas AlfarsiDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha 65799, Saudi Arabia.
Abdulrahman AlhadhramiDepartment of Chemistry, Faculty of Science, Taif University, Taif 21974, Saudi Arabia.
Esam A AlqurashiDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha 65799, Saudi Arabia.
Mohammad Mahboob AlamDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha 65799, Saudi Arabia.ORCID 0000-0003-4801-8800
Al Baha University · SAKing Khalid University · SATaif University · SAAl-Azhar University · EG

Funding

Taif University TURSP-2020/44
6 · The paper itself

Abstract

In the current study, new benzimidazole-based 1,3,4-oxadiazole derivatives have been synthesized and characterized by NMR, IR, MS, and elemental analysis. The final compounds were screened for cytotoxicity against MDA-MB-231, SKOV3, and A549 cell lines and EGFR for inhibitory activities. Compounds

Indexed as

Antineoplastic AgentsProtein Kinase InhibitorsApoptosisBenzimidazolesCell Cycle CheckpointsCell Line, TumorCell ProliferationDoxorubicinDrug Screening Assays, AntitumorErbB ReceptorsErlotinib HydrochlorideMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsBenzimidazolesDoxorubicinErbB ReceptorsErlotinib HydrochlorideProtein Kinase Inhibitors1,3,4-oxadiazoleapoptosisbenzimidazolecell cycle arrestdocking

Identifiers

PMID36296495
PMCPMC9607330
OpenAlexW4306399260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.