Evidence map›Paper›PMID 36296487›Full record

ArticleMolecules (Basel, Switzerland)2022

Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats.

Noemi Oliveira Monteiro, Theresa de Moura Monteiro, Thalya Soares R Nogueira, Jacqueline Rodrigues Cesar, Lara Pessanha S Nascimento, Karoline Azerêdo Campelo, Graziela Rangel Silveira, Fernanda Antunes, Daniela Barros de Oliveira, Almir Ribeiro de Carvalho Junior and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Noemi Oliveira MonteiroLaboratório de Tecnologia de Alimentos, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.ORCID 0000-0003-1905-8846
Theresa de Moura MonteiroLaboratório de Clínica e Cirurgia Animal, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil.
Thalya Soares R NogueiraLaboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.ORCID 0000-0001-9287-9750
Jacqueline Rodrigues CesarLaboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.
Lara Pessanha S NascimentoLaboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.
Karoline Azerêdo CampeloLaboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.
Graziela Rangel SilveiraLaboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.
Fernanda AntunesLaboratório de Clínica e Cirurgia Animal, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil.
Daniela Barros de OliveiraLaboratório de Tecnologia de Alimentos, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.
Almir Ribeiro de Carvalho JuniorInstituto Federal de Educação, Ciência e Tecnologia da Bahia, Vitória da Conquista, Bahia 45078-300, Brazil.
Raimundo Braz-FilhoLaboratório de Clínica e Cirurgia Animal, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil.ORCID 0000-0001-7217-3494
Ivo José Curcino VieiraLaboratório de Tecnologia de Alimentos, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.ORCID 0000-0002-2724-0106
State University of Norte Fluminense · BRInstituto Federal da Bahia · BRUniversidade Federal Rural do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.

Indexed as

AlkaloidsAspidospermaAnimalsAntihypertensive AgentsIndole AlkaloidsRatsRats, WistarAlkaloidsAntihypertensive AgentsIndole AlkaloidsalkaloidAspidocarpineAspidosperma desmanthumblood pressurerotarod

Identifiers

PMID36296487
PMCPMC9609921
OpenAlexW4306398984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.