Evidence map›Paper›PMID 36296455›Full record

ArticleMolecules (Basel, Switzerland)2022

The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents.

Anna Brodzka, Paweł Kowalczyk, Damian Trzepizur, Dominik Koszelewski, Karol Kramkowski, Mateusz Szymczak, Aleksandra Wypych, Rafał Lizut, Ryszard Ostaszewski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Anna BrodzkaInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-6659-0758
Paweł KowalczykDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0003-4025-3750
Damian TrzepizurInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0001-6435-624X
Dominik KoszelewskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0003-0968-3330
Karol KramkowskiDepartment of Physical Chemistry, Medical University of Bialystok, Kilińskiego 1 Str., 15-089 Białystok, Poland.
Mateusz SzymczakDepartment of Molecular Virology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Aleksandra WypychCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Toruń, Wileńska 4, 87-100 Toruń, Poland.ORCID 0000-0002-0555-8690
Rafał LizutInstitute of Mathematics, Informatics and Landscape Architecture, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland.ORCID 0000-0002-6067-1469
Ryszard OstaszewskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-3032-196X
Institute of Organic Chemistry · PLJohn Paul II Catholic University of Lublin · PLKielanowski Institute of Animal Physiology and Nutrition · PLMedical University of Białystok · PLNicolaus Copernicus University · PLUniversity of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on cytotoxic activity was studied. The organophosphonates were obtained based on developed palladium-catalyzed α, β-homodiarylation of vinyl esters protocol. The new synthetic pathway toward 1,2-bis(4-((diethoxyphosphoryl)methyl)phenyl)ethyl acetate was proposed which significantly improves the overall yield of the final product (from 1% to 38%). Several newly synthesized organophosphonates were tested as new potential antimicrobial drugs on model

Indexed as

Anti-Infective AgentsOrganophosphonatesAnti-Bacterial AgentsBacteriaBleomycinCiprofloxacinCloxacillinDNA, BacterialEscherichia coliEstersMicrobial Sensitivity TestsPalladiumAnti-Bacterial AgentsAnti-Infective AgentsBleomycinCiprofloxacinCloxacillinDNA, BacterialEstersOrganophosphonatesPalladiumantimicrobial activitybenzylphosphonatesFpg protein-formamidopyrimidinelipopolysaccharide (LPS)

Identifiers

PMID36296455
PMCPMC9612312
OpenAlexW4306153569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.