Evidence map›Paper›PMID 36296430›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis and Biological Evaluation of Lophanic Acid Derivatives as Antifungal and Antibacterial Agents.

Xiang Yu, Xun Song, Yi Zhang, Yemeng Yang, Jianghai Ye, Yahua Liu, Lutai Pan, Hongjie Zhang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiang YuThe Key Laboratory of Miao Medicine of Guizhou Province, School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Xun SongSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.ORCID 0000-0002-2566-3519
Yi ZhangThe Key Laboratory of Miao Medicine of Guizhou Province, School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Yemeng YangSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.
Jianghai YeThe Key Laboratory of Miao Medicine of Guizhou Province, School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Yahua LiuThe Key Laboratory of Miao Medicine of Guizhou Province, School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Lutai PanThe Key Laboratory of Miao Medicine of Guizhou Province, School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Hongjie ZhangSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.ORCID 0000-0002-7175-5166

Funding

Guizhou Provincial Natural Science Foundation QKH-J(2020)1Y070
6 · The paper itself

Abstract

In order to discover more promising antifungal and antibacterial agents, a series of new derivatives were designed and synthesized by structure modification based on the naturally occurring antimicrobial compound lophanic acid. The structures of all the target compounds were well characterized by spectroscopic data. The stereochemistry of these compounds was further determined through the X-ray diffraction analysis of 6a. The synthetic compounds were evaluated for their antimicrobial activities against filamentous fungi (

Indexed as

Antifungal AgentsAnti-Infective AgentsAnti-Bacterial AgentsCandida albicansEscherichia coliEstersFungiGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsEstersantibacterial activityantifungal activitylophanic acidstructural modification

Identifiers

PMID36296430
PMCPMC9611534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.