Evidence map›Paper›PMID 36296416›Full record

ArticleMolecules (Basel, Switzerland)2022

Elucidation of Binding Features and Dissociation Pathways of Inhibitors and Modulators in SARS-CoV-2 Main Protease by Multiple Molecular Dynamics Simulations.

Lei Xu, Liangxu Xie, Dawei Zhang, Xiaojun Xu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lei XuInstitute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213001, China.ORCID 0000-0002-4095-6539
Liangxu XieInstitute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213001, China.
Dawei ZhangInstitute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213001, China.
Xiaojun XuInstitute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou 213001, China.ORCID 0000-0002-6380-698X
Jiangsu University of Technology · CN

Funding

National Natural Science Foundation of China 81803430
6 · The paper itself

Abstract

COVID-19 can cause different neurological symptoms in some people, including smell, inability to taste, dizziness, confusion, delirium, seizures, stroke, etc. Owing to the issue of vaccine effectiveness, update and coverage, we still need one or more diversified strategies as the backstop to manage illness. Characterizing the structural basis of ligand recognition in the main protease (M

Indexed as

COVID-19 Drug TreatmentMolecular Dynamics SimulationAntiviral AgentsCoronavirus 3C ProteasesHumansLigandsMolecular Docking SimulationProtease InhibitorsSARS-CoV-2Viral Nonstructural Proteins3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesLigandsProtease InhibitorsViral Nonstructural Proteinsbinding featuresCOVID-19drug designMCCSmolecular dynamics simulationsMpro

Identifiers

PMID36296416
PMCPMC9609290
OpenAlexW4304689382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.