ArticleMolecules (Basel, Switzerland)2022
Optimization of Lipid Extraction from
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ultrasound-Assisted Lipid Extraction from Chlorella sp.: Taguchi Design and Life Cycle Assessment.Molecular biotechnology · 2025Article
- Article
- A review on techno-economic assessment of Spirulina for sustainable nutraceutical, medicinal, environmental, and bioenergy applications.Bioresources and bioprocessing · 2025Review
- Eco-Friendly Extraction to Enhance Antioxidants and Nutritional Value inFoods (Basel, Switzerland) · 2025Article
- Applying the Taguchi Method to Improve Key Parameters of Extrusion Vacuum-Forming Quality.Polymers · 2024Article
- The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles ofMolecules (Basel, Switzerland) · 2024Article
- Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary Infections.Pharmaceutics · 2023Article
- Process Optimization and Environmental Analysis of Ultrasound-Assisted Biodiesel Production fromACS omega · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
The present study uses the Taguchi method of experimental design to optimize lipid extraction from Spirulina spp. by ultrasound application and mechanical stirring. A Taguchi L9 orthogonal array was used to optimize various parameters, such as methanol: chloroform (M:C) ratio, biomass: solvent ratio, and extraction time for lipid extraction. The results were analyzed using the signal-to-noise (S/N) ratio and analysis of variance (ANOVA). The biomass: solvent ratio significantly influenced lipid content (p < 0.05) with 92.1% and 92.3% contributions to the lipid and S/N ratio data, respectively. The extraction time presented a contribution value of 5.0%, while the M:C ratio presented the most negligible contribution of 0.4% for S/N data. The optimum extraction conditions were: M:C ratio of 1:1, biomass: solvent ratio of 1:60, and extraction time of 30 min. The predominant fatty acids were palmitic acid (44.5%), linoleic acid (14.9%), and gamma-linolenic acid (13.4%). The confirmation experiments indicated a lipid content of 8.7%, within a 95% confidence interval, proving the Taguchi method’s effectiveness in optimizing the process parameters for lipid extraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.