Evidence map›Paper›PMID 36296265›Full record

ReviewMicroorganisms2022

Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds.

Daniel J Caruso, Enzo A Palombo, Simon E Moulton, Bita Zaferanloo

Abstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Unique tree: Foliar endophytic fungi of the critically endangered Andreadoxa flava (Rutaceae) in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  9. Unveiling the Potential of EndophyticFoods (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Community Structure Diversity of Endophytic Fungi inJournal of fungi (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Bioprospecting of Endolichenic FungusIndian journal of microbiology · 2025
    Article
  14. Article
  15. Article
  16. PeerJ · 2025
    Article
  17. Endophytic Fungi ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Isolation and Identification ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  20. Draft genome sequence of endophytic fungusMicrobiology resource announcements · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel J CarusoDepartment of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Enzo A PalomboDepartment of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.ORCID 0000-0001-5889-1393
Simon E MoultonDepartment of Engineering Technologies, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Bita ZaferanlooDepartment of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last few decades, many of the existing drugs used to treat infectious diseases have become increasingly ineffective due to the global emergence of antimicrobial resistance (AMR). As such, there is a constant demand to find new, effective compounds that could help to alleviate some of this pressure. Endophytic fungi have captured the attention of many researchers in this field, as they have displayed a vast ability to produce novel bioactive compounds, many of which possess wide-ranging antimicrobial activities. However, while highly promising, research in this area is still in its infancy. Endophytes inhabit the healthy tissues of plants asymptomatically, resulting in a mutualistic symbiosis in which the endophytes produce a plethora of bioactive compounds that support the fitness of the host plant. These compounds display great chemical diversity, representing structural groups, such as aliphatic compounds, alkaloids, peptides, phenolics, polyketides and terpenoids. In this review, the significant antimicrobial potential of endophytic fungi is detailed, highlighting their ability to produce novel and diverse antimicrobial compounds active against human, plant and marine pathogens. In doing so, it also highlights the significant contributions that endophytic fungi can make in our battle against AMR, thus providing the motivation to increase efforts in the search for new and effective antimicrobial drugs.

Indexed as

antibiofilmantimicrobialantimicrobial resistancebioactive compoundsendophytesnatural productsnovel

Identifiers

PMID36296265
PMCPMC9607381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.