Evidence map›Paper›PMID 36296162›Full record

ArticleMicroorganisms2022

NFκB1 Polymorphisms Are Associated with Severe Influenza A (H1N1) Virus Infection in a Canadian Population.

Suhrobjon Mullo Mirzo, Anand Kumar, Naresh Kumar Sharma, Lin Li, Robert Balshaw, Francis A Plummer, Ma Luo, Binhua Liang

Abstract read
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In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suhrobjon Mullo MirzoMax Rady College of Medicine, University of Manitoba, Winnipeg, MB R3X 0P3, Canada.
Anand KumarDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Naresh Kumar SharmaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Lin LiJC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory, Winnipeg, MB R3E 3L5, Canada.
Robert BalshawData Sciences Platform, George & Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB R3X 0T6, Canada.ORCID 0000-0002-2455-8792
Francis A PlummerDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Ma LuoDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Binhua LiangJC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory, Winnipeg, MB R3E 3L5, Canada.

Funding

Manitoba Medical Service Foundation N/A
6 · The paper itself

Abstract

Background: We examined associations between NFκB1 polymorphisms and influenza A (H1N1) clinical outcomes in Canadian. Methods: A total of thirty-six Caucasian patients admitted to the intensive care unit (ICU) in hospitals in Canada were recruited during the 2009 H1N1 pandemic. Genomic DNA was extracted from the whole blood samples. The NFkB1 gene was targeted for genotyping using next-generation sequencing technology—Roche 454. Results: A total of 136 single nucleotide polymorphisms (SNPs) were discovered within the NFκB1 gene. Among them, 63 SNPs were significantly enriched in patients admitted in the ICU (p < 0.05) compared with the British Caucasian population in the 1000 Genomes study. These enriched SNPs are mainly intron variants, and only two are exon SNPs from the non-transcribing portion of the NFκB1 gene. Conclusions: Genetic variations in the NFκB1 gene could influence clinical outcomes of pandemic H1N1 infections. Our findings showed that sequence variations of the NFκB1 gene might influence patient response to influenza infection.

Indexed as

H1N1influenzaNFκB1severeSNP

Identifiers

PMID36296162
PMCPMC9606957

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