Evidence map›Paper›PMID 36295690›Full record

ArticleMembranes2022

Microtransplantation of Postmortem Native Synaptic mGluRs Receptors into

Brice Miller, Naomi Moreno, Berenice A Gutierrez, Agenor Limon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brice MillerMitchell Center for Neurodegenerative Diseases, Department of Neurology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Naomi MorenoMitchell Center for Neurodegenerative Diseases, Department of Neurology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Berenice A GutierrezMitchell Center for Neurodegenerative Diseases, Department of Neurology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-2756-1970
Agenor LimonMitchell Center for Neurodegenerative Diseases, Department of Neurology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-6613-770X
The University of Texas Medical Branch at Galveston · US

Funding

Tau oligomer conformers and synaptic vulnerability/resilience in AD and related disordersR01AG073133 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LIMON, AGENOR, TAGLIALATELA, GIULIO · 2021 to 2025
$3.8M
Mechanisms of Synaptic Protection in Cognitive Resilence to Alzheimer's Disease NeuropathologyR01AG070255 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LIMON, AGENOR · 2021 to 2025
$2.2M
NIA NIH HHS AG070255NIA NIH HHS R01 AG070255NIA NIH HHS R01 AG073133
6 · The paper itself

Abstract

Metabotropic glutamate receptors (mGluRs) are membrane receptors that play a central role in the modulation of synaptic transmission and neuronal excitability and whose dysregulation is implicated in diverse neurological disorders. Most current understanding about the electrophysiological properties of such receptors has been determined using recombinant proteins. However, recombinant receptors do not necessarily recapitulate the properties of native receptors due to the lack of obligated accessory proteins, some of which are differentially expressed as function of developmental stage and brain region. To overcome this limitation, we sought to microtransplant entire synaptosome membranes from frozen rat cortex into

Indexed as

G-protein coupled receptorsmGluRmicrotransplantation of synaptic membranesphospholipase Cpost-mortem

Identifiers

PMID36295690
PMCPMC9609105
OpenAlexW4297235490

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.