Evidence map›Paper›PMID 36295581›Full record

Trial reportMedicina (Kaunas, Lithuania)2022

Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late?

Matteo Cavaliere, Pietro De Luca, Alfonso Scarpa, Adriano Maciej Strzalkowski, Massimo Ralli, Matteo Calvanese, Luisa Savignano, Pasquale Viola, Claudia Cassandro, Giuseppe Chiarella and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Matteo CavaliereDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84131 Salerno, Italy.
Pietro De LucaDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84131 Salerno, Italy.ORCID 0000-0002-6505-1680
Alfonso ScarpaDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84131 Salerno, Italy.
Adriano Maciej StrzalkowskiDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84131 Salerno, Italy.ORCID 0000-0002-8981-4654
Massimo RalliDepartment of Sense Organs, University La Sapienza, 00185 Rome, Italy.ORCID 0000-0001-8776-0421
Matteo CalvaneseDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84131 Salerno, Italy.
Luisa SavignanoDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84131 Salerno, Italy.
Pasquale ViolaUnit of Audiology, Regional Centre for Cochlear Implants and ENT Diseases, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-2352-1146
Claudia CassandroSurgical Sciences Department, University of Turin, 10126 Turin, Italy.
Giuseppe ChiarellaUnit of Audiology, Regional Centre for Cochlear Implants and ENT Diseases, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-9829-2229
Arianna Di StadioDepartment G.F. Ingrassia, University of Catania, 95124 Catania, Italy.ORCID 0000-0001-5510-3814
University of Salerno · ITMagna Graecia University · ITSapienza University of Rome · ITUniversity of Catania · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Several treatments are available for sudden sensorineural hearing loss (SSNHL), but no studies have compared the different treatments based on the delay from the onset of the disease. Our study aims to compare the effect of hyperbaric oxygen therapy (HBOT), oral steroids (OS) and combination of both therapies (HBOT + OS) for treating SSNHL. Materials and Methods: This randomized study analyzed 171 patients with SSNHL. Patients were evaluated by pure tone audiometry test (PTA) at baseline (T0) and 20 days after treatment (T1). Three groups were available HBOT-A-, OS-B- and HBOT + OS-C-. After baseline PTA, patients were randomly assigned to each group. Statistical analysis was performed by one-way ANOVA and Chi-square. Results: Patients in the HBOT + OS and HBOT groups improved their auditory function (p < 0.05). HBOT was the best choice for treatment when started by 7 days from SSNHL onset, while HBOT + OS in case of late treatment. Profound SNHL recovered equally by HBOT and HBOT + OS (p < 0.05). Upsloping SNHL obtained better auditory results by HBOT compared to HBOT + OS (p < 0.05). Downsloping and flat SSNHL had the most improvement with HBOT + OS compared to HBOT only (p < 0.05). Conclusions: Combination of HBOT and OS is a valid treatment for SSNHL both in case of early and late treatment. Combination of HBOT and OS was the choice with the best results in case of treatment started >14 days from symptom onset.

Indexed as

Hearing Loss, SensorineuralHearing Loss, SuddenHyperbaric OxygenationHumansRetrospective StudiesSteroidsTreatment OutcomeSteroidsHBOThyperbaric oxygen therapyidiopathic sudden hearing losssteroid therapysudden deafness

Identifiers

PMID36295581
PMCPMC9611781
OpenAlexW4303981455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.