Evidence map›Paper›PMID 36295528›Full record

ArticleMedicina (Kaunas, Lithuania)2022

Successful Phakic Intraocular Lens Implantation with the Usage of Topical Ascorbic Acid in Patient with Reduced Corneal Endothelial Cell Density.

Hung-Chi Chen, Chia-Yi Lee, Chao-Min Cheng, Yi-Jen Hsueh, Chao-Kai Chang, Wei-Chi Wu

Open access · goldAbstract readCase Reports
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Hung-Chi ChenDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.ORCID 0000-0002-1117-7878
Chia-Yi LeeInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0002-5719-0488
Chao-Min ChengInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-8644-1960
Yi-Jen HsuehDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.ORCID 0000-0003-3380-7188
Chao-Kai ChangNobel Eye Institute, Taipei 100008, Taiwan.
Wei-Chi WuDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TWDayeh University · TWJen-Ai Hospital · TWNational Tsing Hua University · TW

Funding

Chang Gung Memorial Hospital CRRPG3M0071Ministry of Science and Technology MOST 110-2221-E-182A-006-
6 · The paper itself

Abstract

We aimed to describe the use of topical ascorbic acid (AA) in a patient with reduced endothelial cells density (ECD) who was scheduled for phakic intraocular lens (pIOL) implantation. A 28-year-old woman presenting with dry eye and reduced ECD would like to have her high myopia (spherical equivalence >−15.0 D) corrected. The procedure of laser refractive surgery or even pIOL was not indicated for the reduced ECD of 1865/mm2 in the right eye and 2188/mm2 in the left eye, as well as level 3 dry eye. Fortunately, the ECD increased to 3144/mm2 in the right eye and 2538/mm2 in the left eye after topical AA was prescribed for one year preoperatively and one month postoperatively, with concomitant improvement of dry eye to level 1. Finally, bilateral pIOL implantation was performed smoothly and no sign of corneal decompensation was found postoperatively. Three months postoperatively, the ECD showed a satisfactory level of 2983/mm2 in the right eye and 3003/mm2 in the left eye. In conclusion, topical AA instillation might increase and maintain the density of central human corneal endothelial cells (HCECs) even after pIOL implantation.

Indexed as

Phakic Intraocular LensesAdultAscorbic AcidCell CountEndothelial CellsEndothelium, CornealFemaleFollow-Up StudiesHumansIrisLens Implantation, IntraocularVisual AcuityAscorbic Acidascorbic acidcorneal endotheliumendothelial cell densityphakic intraocular lens

Identifiers

PMID36295528
PMCPMC9610942
OpenAlexW4297523329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.