ArticleMaterials (Basel, Switzerland)2022
Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds.
Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 21 citations in OpenAlex.
- Mechanobiological optimization of scaffolds for bone tissue engineering.Biomechanics and modeling in mechanobiology · 2024Article
- Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds.Journal of functional biomaterials · 2023Article
- Direct Integration of 3D Printing and Cryogel Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023Article
- Novel 3D printed TPMS scaffolds: microstructure, characteristics and applications in bone regeneration.Journal of tissue engineeringReview
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
When designing scaffolds for bone tissue engineering (BTE), the wall shear stress (WSS), due to the fluid flow inside the scaffold, is an important factor to consider as it influences the cellular process involved in new tissue formation. The present work analyzed the average WSS in Schwartz diamond (SD) and gyroid (SG) scaffolds with different surface topologies and mesh elements using computational fluid dynamics (CFD) analysis. It was found that scaffold meshes with a smooth surface topology with tetrahedral elements had WSS levels 35% higher than the equivalent scaffold with a non-smooth surface topology with hexahedral elements. The present work also investigated the possibility of implementing the optimization algorithm simulated annealing to aid in the design of BTE scaffolds with a specific average WSS, with the outputs showing that the algorithm was able to reach WSS levels in the vicinity of 5 mPa (physiological range) within the established limit of 100 iterations. This proved the efficacy of combining CFD and optimization methods in the design of BTE scaffolds.
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