Evidence map›Paper›PMID 36295036›Full record

ArticleLife (Basel, Switzerland)2022

Rhombencephalitis in Pregnancy-A Challenging Case of Probable

Alison E P Ho, Zahirrah B M Rasheed, James Norman, Carolyn Gabriel, Luke Dixon, Simon Ashworth, Charlotte Frise, Christina K H Yu, Lynne Sykes

Open access · goldAbstract readCase Reports
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alison E P HoSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Zahirrah B M RasheedUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-4212-8921
James NormanSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Carolyn GabrielSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Luke DixonSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Simon AshworthSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Charlotte FriseSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.ORCID 0000-0002-7650-5780
Christina K H YuSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.
Lynne SykesSt. Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.ORCID 0000-0002-7806-5707
Imperial College Healthcare NHS Trust · GBUniversity Kebangsaan Malaysia Medical Centre · MY

Funding

Majlis Amanah Rakyat (MARA), Malaysian Government Agency 1111National Institute for Health Research Comprehensive Biomedical Research Centre at Imperial College P45272The Parasol Foundation DRP2122_05
6 · The paper itself

Abstract

Rhombencephalitis refers to inflammation of the brainstem and cerebellum, and can be caused by infections, autoimmune disorders or paraneoplastic syndromes. The most common infective cause is the bacterium Listeria monocytogenes. Listeria monocytogenes is the predominant species to cause human listeriosis, and is commonly due to the ingestion of contaminated foods. Symptoms include a mild gastroenteritis, fever (often with extreme temperature variations), headache, and myalgia. In more severe cases, invasive disease may lead to bacteraemia and neurolisteriosis. Pregnant women are more susceptible to listeriosis, which is believed to be due to pregnancy-related immune modulation. Maternal-neonatal infection with adverse pregnancy outcomes include neonatal listeriosis, spontaneous miscarriage and intrauterine fetal demise. Diagnosis may be challenging due to initial nonspecific symptoms and low sensitivity and specificity of confirmatory diagnostic laboratory tests. Here, we describe a case of rhombencephalitis in pregnancy, attributed to Listeria, and review the clinical features, diagnosis and multidisciplinary management. Lastly, we describe the immunological response to Listeria monocytogenes and show in vitro pro-inflammatory effects of Listeria monocytogenes on peripheral blood mononuclear cells and placental explants.

Indexed as

Listeria monocytogenespregnancyrhombencephalitis

Identifiers

PMID36295036
PMCPMC9604870
OpenAlexW4306392958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.