ArticleLife (Basel, Switzerland)2022
C-Reactive Protein as a Potential Peripheral Biomarker for High-Lethality Suicide Attempts.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 12 citations in OpenAlex.
- Distinct effects of current suicidal symptoms and lifetime suicide attempts on C-reactive protein levels and executive function in young people with major affective disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Levels of matrix metalloproteinase 9 (MMP-9) are elevated in persons with major depressive disorder who have had a recent suicide attempt.Brain, behavior, & immunity - health · 2026Article
- Inflammatory Parameters in Patients with Suicide Attempts by Drug Overdose: A Comparative Study with a Comparison Group.Medicina (Kaunas, Lithuania) · 2026Observational
- Low-grade inflammatory parameters may be associated with recent suicide attempts - a naturalistic study among psychiatric inpatients with depressive disorders.Frontiers in psychiatry · 2026Article
- Clinical Outcomes Following Suicide Attempts: In-Hospital Mortality and Discharge Against Medical Advice.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Observational
- Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults.The international journal of neuropsychopharmacology · 2024Article
- Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates.Frontiers in immunology · 2024Review
- Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors-A Narrative Review.Brain sciences · 2023Review
- [ROC curves: general characteristics and their usefulness in clinical practice].Revista medica del Instituto Mexicano del Seguro Social · 2023Article
- Association between Psychological, Biochemical and Personal Factors with the Inflammatory Marker High-Sensitive C Reactive Protein (Hs-CRP) in Mexican Healthy Population.Journal of personalized medicine · 2023Article
- Cardiovascular autonomic dysfunction in "Long COVID": pathophysiology, heart rate variability, and inflammatory markers.Frontiers in cardiovascular medicine · 2023Review
- High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts: A Preliminary Case-Control Study.International journal of environmental research and public health · 2022Article
- Association of interleukin-6 (IL-6) with suicide attempt.Industrial psychiatry journalArticle
- High molar ratios of tumor necrosis factorThe European journal of psychiatryArticle
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to identify a cut-off of c-reactive protein (c-RP) potentially predictive of high-lethality suicide attempts (SA) in an inpatient psychiatric sample. After attempting suicide, subjects were admitted to the emergency ward of the IRCCS Ospedale Policlinico San Martino and later to the section of Psychiatry from 1 August 2013 to 31 July 2018. C-reactive protein was measured. The Area Under the Receiver Operating Characteristic (ROC_AUC) was used to assess the discriminative capacity of c-RP for high- vs. low-lethality SA, and a logistic regression was performed to detect the odds ratio, adjusted for age and sex. High-lethality suicide attempters were 133 (30.8%), while low-lethality suicide attempters were 299 (69.2%). The optimal cut-off threshold (and corresponding sensitivity and specificity values) for c-RP was 4.65 mg/L (68/71%). This cut-off corresponds to an AUC of 73.5%. An odds ratio of 4.70 was generated for current high-lethality SA after a logistic regression, adjusted for age and sex. Research on social and biological factors underlying the lethality of SA is crucial for a better understanding of this complex phenomenon. Identifying potential predictors of SA, especially those at high lethality, is essential to implement personalized preventive strategies.
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