ArticleLife (Basel, Switzerland)2022
Olive Leaf Extract Attenuates Chlorpyrifos-Induced Neuro- and Reproductive Toxicity in Male Albino Rats.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 25 citations in OpenAlex.
- Neuroprotective Effects of Senecio brasiliensis Extract Against Chlorpyrifos-Induced Neurotoxicity and Oxidative Stress in Drosophila melanogaster.Basic & clinical pharmacology & toxicology · 2026Article
- Olive leaf extract attenuates acrylamide-induced reproductive toxicity through reduced oxidative DNA damage and apoptosis associated with 8-OHdG and Caspase-3 in rats.Journal of molecular histology · 2026Article
- Jojoba Oil Protects against Chlorpyrifos-Induced Testicular Toxicity by Modulating Notch1/Jagged1-Inflammatory Axis and Oxidative Stress.Cell biochemistry and biophysics · 2026Article
- Protective Effects ofToxics · 2025Article
- Zinc nanoparticles mitigate azoxystrobin and its nanoencapsulation-induced hepatic and renal toxicity in rats.Redox report : communications in free radical research · 2025Article
- Teratogenic effects of thiamethoxam on female rats and possible protective function of ascorbic acid.Open veterinary journal · 2025Article
- The effect of an organophosphorus pesticide, chlorpyrifos (from different local sources), on the testicular tissue in adult male albino rats.Environmental analysis, health and toxicology · 2025Article
- The Ameliorative Effect ofFoods (Basel, Switzerland) · 2024Article
- Protective effect of vitamin C against thiamethoxam-induced toxicity in male rats.Open veterinary journal · 2023Article
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Pesticide Residues in Vegetables and Fruits from Farmer Markets and Associated Dietary Risks.Molecules (Basel, Switzerland) · 2022Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorpyrifos (CPF) is a common organophosphorus insecticide. It is associated with negative consequences such as neurotoxicity and reproductive injury. This study aimed to observe the ability of olive leaf extract to attenuate chlorpyrifos toxicity, which induced neuro- and reproductive toxicity in male albino rats. Olive leaf extract (OLE) exhibits potent antioxidant and antiapoptotic properties. Twenty-two mature male rats were divided into four groups: control (saline), CPF (9 mg/kg), OLE (150 mg/kg), and CPF + OLE. Treatment was administered orally for 80 days. The CPF significantly reduced serum sex hormones, sperm counts and motility, high oxidants (MDA), and depleted antioxidants (GSH, SOD, TAC) in the brain and testes homogenate; additionally, it decreased serum AChE and brain neurotransmitters, increased
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