Evidence map›Paper›PMID 36294874›Full record

ArticleJournal of personalized medicine2022

Serum Adiponectin, a Novel Biomarker Correlates with Skin Thickness in Systemic Sclerosis.

Giorgia Leodori, Chiara Pellicano, Valerio Basile, Amalia Colalillo, Luca Navarini, Antonietta Gigante, Francesca Gulli, Mariapaola Marino, Umberto Basile, Edoardo Rosato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Giorgia LeodoriDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00189 Rome, Italy.
Chiara PellicanoDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0003-1077-4846
Valerio BasileClinical Pathology Unit and Cancer Biobank, Department of Research and Advanced Technologies, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Amalia ColalilloDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00189 Rome, Italy.
Luca NavariniUnit of Allergology, Clinical Immunology and Rheumatology, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Antonietta GiganteDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-2015-765X
Francesca GulliClinical Biochemistry Laboratory, IRCCS "Bambino Gesù" Children's Hospital, 00165 Rome, Italy.
Mariapaola MarinoDepartment of Translational Medicine and Surgery, Section of General Pathology, "A. Gemelli" IRCCS, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0001-9155-6378
Umberto BasileDepartment of Laboratory and Infectious Disease Sciences, "A. Gemelli" IRCCS, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-8328-2570
Edoardo RosatoDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-7417-8093
Sapienza University of Rome · ITUniversità Cattolica del Sacro Cuore · ITBambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversità Campus Bio-Medico · IT

Funding

Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario "A. Gemelli" IRCCS part of its programs on promotion and dissemination of scientific research (Linea D1 to MM).
6 · The paper itself

Abstract

The aim was to evaluate the longitudinal association between basal serum adiponectin and repeated measurements of skin thickness during 12 months of follow-up in systemic sclerosis (SSc) patients. We enrolled SSc patients with disease duration > 2 years in a prospective observational study. Skin thickness was measured at baseline and after 12 months of follow-up with modified Rodnan skin score (mRSS). Baseline serum adiponectin was determined using a commercial ELISA kit. We enrolled 66 female SSc patients (median age 54 years, IQR 42−62 years). The median disease duration was 12 (IQR 8−16) years and median baseline serum adiponectin was 9.8 (IQR 5.6−15.6) mcg/mL. The median mRSS was 10 (IQR 6−18) at baseline and 12 (IQR 7−18) at follow-up. A significant correlation was observed between baseline serum adiponectin and disease duration (r = 0.264, p < 0.05), age (r = 0.515, p < 0.0001), baseline mRSS (r = −0.303, p < 0.05), and mRSS at follow-up (r = −0.322, p < 0.001). In multiple regression analysis, only mRSS at follow-up showed an inverse correlation with baseline serum adiponectin (β = −0.132, p < 0.01). The reduction in serum adiponectin levels is correlated with skin thickness.

Indexed as

adiponectinbiomarkersskin thicknesssystemic sclerosis

Identifiers

PMID36294874
PMCPMC9604668
OpenAlexW4306773715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.