Evidence map›Paper›PMID 36294747›Full record

ArticleJournal of personalized medicine2022

Identification of Patients with Potential Atrial Fibrillation during Sinus Rhythm Using Isolated P Wave Characteristics from 12-Lead ECGs.

Hui-Wen Yang, Cheng-Yi Hsiao, Yu-Qi Peng, Tse-Yu Lin, Lung-Wen Tsai, Chen Lin, Men-Tzung Lo, Chun-Ming Shih

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Identification of Brugada syndrome based on P-wave features: an artificial intelligence-based approach.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui-Wen YangDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-6847-3272
Cheng-Yi HsiaoDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan City 320317, Taiwan.
Yu-Qi PengDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan City 320317, Taiwan.
Tse-Yu LinDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan City 320317, Taiwan.
Lung-Wen TsaiDepartment of Medicine Research, Taipei Medical University Hospital, Taipei 110301, Taiwan.ORCID 0000-0002-3541-5834
Chen LinDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan City 320317, Taiwan.ORCID 0000-0001-6261-8509
Men-Tzung LoDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan City 320317, Taiwan.ORCID 0000-0003-2630-4945
Chun-Ming ShihDivision of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110301, Taiwan.

Funding

Taiwan Ministry of Science and Technology 108-2221-E-008-040-MY3Taiwan Ministry of Science and Technology 108-2221-E-008-095-MY2Taiwan Ministry of Science and Technology 109-2823-8-008-002-CVTaiwan Ministry of Science and Technology 110-2221-E-008-093
6 · The paper itself

Abstract

Atrial fibrillation (AF) is largely underdiagnosed. Previous studies using deep neural networks with large datasets have shown that screening AF with a 12-lead electrocardiogram (ECG) during sinus rhythm (SR) is possible. However, the poor availability of these trained models and the small size of the retrievable datasets limit its reproducibility. This study proposes an approach to generate explainable features for detecting AF during SR with limited data. We collected 94,224 12-lead ECGs from 64,196 patients from Taipei Medical University Hospital. We selected ECGs during SR from 213 patients before AF diagnosis and randomly selected 247 age-matched participants without AF records as the controls. We developed a signal-processing technique, MA-UPEMD, to isolate P waves, and quantified the spatial and temporal features using principal component analysis and inter-lead relationships. By combining these features, the machine learning models yielded AUC of 0.64. We showed that, even with this limited dataset, the P wave, representing atrial electrical activity, is depicted by our proposed approach. The extracted features performed better than the bandpass filter-extracted P waves and deep neural network model. We provided a physiologically explainable and reproducible approach for classifying patients with AF during SR.

Indexed as

atrial fibrillationcardiovascular disease diagnosisempirical mode decompositionimpulse noiseinter-lead dispersionmachine learningphysiological time seriessignal processingspike

Identifiers

PMID36294747
PMCPMC9604932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.